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Chemical Compound Review:

Mra-CN 4-[3-hydroxy-2-methyl-6- [[3,5,12...

Synonyms: AGN-PC-00EE72, CCRIS 5080, Neuro_000195, NSC-639650, NSC-639651, ...

Chen, Y.N. et al., Westendorf, J. et al., Westendorf, J. et al., Acton, E.M. et al., Cullinane, C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mra-CN

Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin [1].
The two new potent anthracycline antitumor antibiotics, morpholinodaunomycin and cyanomorpholinoadriamycin, are non-mutagenic or weakly mutagenic in Salmonella typhimurium or V79 Chinese hamster cells, but highly active inducing DNA repair in in cultured rat hepatocytes [2].

High impact information on Mra-CN

It exhibits a unique cross-resistance pattern: high cross-resistance to the potent Adr analogue 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin, lower cross-resistance to the alkylating agent melphalan, and a sensitivity similar to the parental cell line to vinblastine [3].
N-(2-hydroxyethyl)doxorubicin from hydrolysis of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin [4].
The DNA sequence specificity of cyanomorpholinoadriamycin [5].

References

Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin. Westendorf, J., Groth, G., Steinheider, G., Marquardt, H. Cell Biol. Toxicol. (1985) [Pubmed]
Induction of malignant transformation in vitro and mammary tumors in rats by two new potent anthracycline antitumor antibiotics, morpholinodaunomycin and cyanomorpholinoadriamycin. Westendorf, J., Mohr, U., Marquardt, H. Cell Biol. Toxicol. (1987) [Pubmed]
Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. Chen, Y.N., Mickley, L.A., Schwartz, A.M., Acton, E.M., Hwang, J.L., Fojo, A.T. J. Biol. Chem. (1990) [Pubmed]
N-(2-hydroxyethyl)doxorubicin from hydrolysis of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin. Acton, E.M., Tong, G.L., Smith, T.H., Taylor, D.L., Streeter, D.G., Peters, J.H., Gordon, G.R., Filppi, J.A., Wolgemuth, R.L., Giuliani, F.C. J. Med. Chem. (1986) [Pubmed]
The DNA sequence specificity of cyanomorpholinoadriamycin. Cullinane, C., Phillips, D.R. FEBS Lett. (1991) [Pubmed]

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