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Chemical Compound Review:

Burchellin 2-benzo[1,3]dioxol-5-yl-5- methoxy-3-methyl...

Synonyms: AGN-PC-000KNL, AG-F-34886, NSC-370991, AC1Q6BIC, CTK1C5053, ...

Cabral, M.M. et al., Cabral, M.M. et al., Garcia, E.S. et al.

Garcia, Cabral, Schaub, Gottlieb, Azambuja,

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High impact information on NSC370991

Therefore, burchellin not only depresses the release of the diuretic hormone or induces the release of antidiuretic factors but also directly affects the Malpighian tubules [1].
Rhodnius prolixus: effects of the neolignan burchellin on in vivo and in vitro diuresis [1].
When Rhodnius prolixus was fed with epimastigotes of T. cruzi and treated simultaneously with a single dose of burchellin or NDGA at 10 pg/ml of blood meal the number of parasites in the gut decreased [2].
Whereas burchellin was only partially active, NDGA drastically reduced the number of epimastigotes and metacyclic trypomastigotes of T. cruzi in the excreta (urine plus feces) [2].

Associations of NSC370991 with other chemical compounds

We conclude that burchellin interfered with the release, but not with the production of diuretic hormone by the thoracic ganglionic mass or induced an antidiuretic hormone and directly affected the Malpighian tubules [3].

References

Rhodnius prolixus: effects of the neolignan burchellin on in vivo and in vitro diuresis. Cabral, M.M., Kollien, A.H., Kleffmann, T., Azambuja, P., Gottlieb, O.R., Garcia, E.S., Schaub, G.A. Parasitol. Res. (2000) [Pubmed]
Neolignans inhibit Trypanosoma cruzi infection of its triatomine insect vector, Rhodnius prolixus. Cabral, M.M., Azambuja, P., Gottlieb, O.R., Garcia, E.S. Parasitol. Res. (1999) [Pubmed]
Effects of lignoids on a hematophagous bug, Rhodnius prolixus: feeding, ecdysis and diuresis. Garcia, E.S., Cabral, M.M., Schaub, G.A., Gottlieb, O.R., Azambuja, P. Phytochemistry (2000) [Pubmed]

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