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Chemical Compound Review

AC1LEL6Z     4-[(2R,3R)-4-(3,4- dihydroxyphenyl)-2,3...

Synonyms: CTK0D8681, ZINC00056474, 103185-28-0
 
 
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Disease relevance of NORDIHYDROGUAIARETIC ACID

  • In this report, we evaluated the growth-inhibitory effects of sulindac sulfide, a COX-1 and COX-2 inhibitor; exisulind (sulindac sulfone), a novel proapoptotic agent that does not inhibit COX enzymes; and nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor on human lung cancer cell lines [1].
  • We conclude that the inhibitors of eicosanoid biosynthesis, NDGA and 5,8,11,14-eicosatetraynoic acid, not only suppress glioblastoma cell proliferation, but also induce increased astrocytic differentiation [2].
  • The inhibited glioma cells demonstrated an increase in the number and length of astrocytic processes containing greater numbers of glial filaments, and the NDGA-treated cells also demonstrated extensive lateral pseudopod formation along the processes [2].
  • The present procedure, implemented in Fortran 90 and named TGSA-Flex, is deeply detailed and tested over four molecular sets: amino acids, nordihydroguaiaretic acid (NDGA) derivatives, HIV-1 protease inhibitors, and 1-[2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives [3].
  • Induction of PCA by Escherichia coli was similarly inhibited (E. coli 10(6) alone = 518 +/- 130; with NDGA 3 microM = 234 +/- 100, n = 2) [4].
 

Psychiatry related information on NORDIHYDROGUAIARETIC ACID

 

High impact information on NORDIHYDROGUAIARETIC ACID

 

Chemical compound and disease context of NORDIHYDROGUAIARETIC ACID

 

Biological context of NORDIHYDROGUAIARETIC ACID

 

Anatomical context of NORDIHYDROGUAIARETIC ACID

 

Associations of NORDIHYDROGUAIARETIC ACID with other chemical compounds

 

Gene context of NORDIHYDROGUAIARETIC ACID

  • To rule out the possibility that NDGA will induce apoptosis because of the effects on proteins other than AP-1, we investigated the effect of another AP-1 inhibitor, SP600125, which is specific to Jun-N-terminal kinase [26].
  • Further evaluation of the apoptotic process revealed that NDGA and BFA induced a rapid dephosphorylation of BAD and decrease expression of Bcl-2 [27].
  • Pretreatment for 15 min with the lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA; 50 microM), but not the cyclooxygenase inhibitor indomethacin (10 microM) or the epoxygenase inhibitor SKF525A (100 microM) inhibited the sustained response to CRF by 48% and the initial spike response to AVP by 38% [28].
  • Our results indicate that treatment of cells with NDGA enhances c-myc, p53, and bax protein levels [26].
  • In addition, volume regulation was inhibited by the lipoxygenase pathway antagonist nordihydroguaiaretic acid (NDGA, 10 microM), the 5 lipoxygenase antagonists AA-861 (5 microM) and curcumin (20 microM), and by the 5-lipoxygenase activating protein inhibitor L-655,298 (5 microM) [29].
 

Analytical, diagnostic and therapeutic context of NORDIHYDROGUAIARETIC ACID

References

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