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Chemical Compound Review

ARGIPRESSIN     (2S)-1- [[(4S,7S,10S,13S,16S,19S)-19- amino...

Synonyms: AVP Diacetate, CHEMBL373742, CHEBI:34543, ABP000578, CAS-113-79-1, ...
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Disease relevance of Pitressin


Psychiatry related information on Pitressin


High impact information on Pitressin


Chemical compound and disease context of Pitressin


Biological context of Pitressin


Anatomical context of Pitressin


Associations of Pitressin with other chemical compounds


Gene context of Pitressin

  • Cold stress for 30 min also stimulates an increase in the percentage of immunoreactive corticotropes and cells that bind CRH or arginine vasopressin (AVP) [33].
  • AVP that participates in the regulation of ACTH release at the pituitary level is produced in two main groups of neurons in the hypothalamus: parvicellular cells in the paraventricular nucleus, which also produce CRF-41, and magnocellular neurons in the supraoptic and paraventricular nuclei [34].
  • Moreover, Trpv1(-/-) mice showed a pronounced serum hyperosmolality under basal conditions and severely compromised AVP responses to osmotic stimulation in vivo [23].
  • Arginine-vasopressin (AVP) is a hormone that is essential for both osmotic and cardiovascular homeostasis, and exerts important physiological regulation through three distinct receptors, V1a, V1b, and V2 [35].
  • The functional viability of these ARC/PVN cultures was verified by their ability to synthesize and secrete CRH, AVP, and beta-END under basal and depolarizing (veratridine) conditions in vitro [36].

Analytical, diagnostic and therapeutic context of Pitressin

  • Molecular cloning of the receptor for human antidiuretic hormone [37].
  • The present studies were designed to, first, determine whether a urinary concentrating defect exists in potassium-depleted rabbits and, second, to use the technique of in vitro perfusion to evaluate directly the antidiuretic hormone (ADH) responsiveness of cortical collecting tubules (CCT) in this setting [38].
  • The effects of maximal physiological doses of arginine-8-vasopressin ([Arg8]VP (herein designated AVP); 20 pg/min per 100 g of body weight) were studied 2 days after the cessation of treatment, when the animals had returned to DI [39].
  • RNase protection and heteroduplex analyses demonstrate that, in heterozygous animals, which express both alleles of the AVP gene, the wild-type but not the mutant transcript is subject to axonal compartmentation [40].
  • Exposure of ARC/PVN cocultures to the glucocorticoid dexamethasone (DEX) resulted in a dose-dependent increase of CRH secretion and an inhibition of AVP and beta-END; the CRH responses deviated strikingly from predictions based on in vivo experiments [36].


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