Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL174366 N,3,4,5-tetrahydroxybenzamide

Synonyms: VF-122, AG-G-72524, CHEBI:390362, NSC-324362, CTK5D1441, ...

Ban, J. et al., Howell, S.B. et al., Oláh, E. et al.

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Disease relevance of VF-122

DBD in combination with VF-122 exhibited additive lethality against hepatoma cells in culture [1].

High impact information on VF-122

In synchronized cultures, VF 122 (1 MM for 1 hr) was toxic for cells in mid and late G1 phase, in early and mid S phase, and, to a lesser degree, in G2 phase, Hydroxyurea (10 mM for 1 hr) killed cells only in S phase [2].
Treatment for 1 hr with VF 122 of exponentially growing culture resulted in a biphasic exponential dose-response curve (Do = 0.5 mM, IC50 = 0.75 mM, and Do = 1.8 mM, IP = 0.8 mM) [2].
Two potent new ribonucleotide reductase inhibitors, 3,4,5-trihydroxybenzohydroxamic acid (VF 122) and 3,4-dihydroxybenzohydroxamic acid (VF 147), were investigated for their ability to modulate the cellular pharmacology of cytarabine (ara-C) in HL-60 cells [3].

References

Potentiation of antimetabolite action by dibromodulcitol in cell culture. Oláh, E., Kremmer, T., Boldizsár, M. Adv. Enzyme Regul. (1985) [Pubmed]
Cytotoxic and cell kinetic effects of 3,4,5-trihydroxybenzohydroxamic acid (VF 122) in hepatoma 3924A cells. Ban, J., Olah, E., Weber, G. Cancer treatment reports. (1982) [Pubmed]
Modulation of cytarabine metabolism in the human promyelocytic leukemia cell line HL-60 by polyhydroxy-substituted benzohydroxamic acids. Howell, S.B., Gill, S., Elford, H.L. Cancer treatment reports. (1982) [Pubmed]

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