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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

isoquinolinol     2H-isoquinolin-1-one

Synonyms: Isocarbostyril, Isoquinolinone, PubChem6257, SureCN57212, SureCN58112, ...
 
 
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High impact information on NSC27273

  • The trans ring juncture of isocarbostyril 3a proved to be an important modification of narciclasine (2a) for improving cancer cell growth inhibition in this series [1].
  • The human cancer cell line inhibitory isocarbostyril precursors were isolated from the bulbs of Hymenocallis littoralis obtained by horticultural production or reduction of narciclasine (1a --> 4) from the same source [2].
  • The isocarbostyril nucleoside compound 1-(2-deoxy-beta-D-ribofuranosyl)-isocarbostyril (EN1) was a poor substrate with all the enzymes [3].
  • These data provide a possible explanation for the previously reported lack of cytotoxicity of the isocarbostyril- and difluorophenyl nucleosides, but potential mitochondrial effects of EN2, JW1 and JW2 should be further investigated [3].
  • Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases [3].
 

Biological context of NSC27273

References

  1. Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine. Pettit, G.R., Eastham, S.A., Melody, N., Orr, B., Herald, D.L., McGregor, J., Knight, J.C., Doubek, D.L., Pettit, G.R., Garner, L.C., Bell, J.A. J. Nat. Prod. (2006) [Pubmed]
  2. Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1). Pettit, G.R., Melody, N. J. Nat. Prod. (2005) [Pubmed]
  3. Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases. Al-Madhoun, A.S., Eriksson, S., Wang, Z.X., Naimi, E., Knaus, E.E., Wiebe, L.I. Nucleosides Nucleotides Nucleic Acids (2004) [Pubmed]
  4. 5-HT1A and 5-HT2A receptor affinity and functional profile of some N-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1H)-one, quinolin-2(1 H)-one and isoquinolin-1(2H)-one. Part 30: Structure-activity relationship studies of CNS agents. Mokrosz, M.J., Mokrosz, J.L., Duszyńska, B., Dereń-Wesołek, A., Kłodzińska, A., Kowalski, P., Charakchieva-Minol, S., Tatarczyńska, E., Kowalska, T., Majka, Z., Chojnacka-Wójcik, E., Misztal, S. Die Pharmazie. (1997) [Pubmed]
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