Gene Review:
Htr2a - 5-hydroxytryptamine (serotonin) receptor 2A
Mus musculus
Synonyms:
5-HT-2, 5-HT-2A, 5-HT2A receptor, 5-hydroxytryptamine receptor 2A, E030013E04, ...
- Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese A(y) mice. Nonogaki, K., Nozue, K., Oka, Y. Biochem. Biophys. Res. Commun. (2006)
- Identification of an endogenous 5-hydroxytryptamine2A receptor in NIH-3T3 cells: agonist-induced down-regulation involves decreases in receptor RNA and number. Saucier, C., Albert, P.R. J. Neurochem. (1997)
- Gene structure and expression of the mouse 5-HT2 receptor. Yang, W., Chen, K., Lan, N.C., Gallaher, T.K., Shih, J.C. J. Neurosci. Res. (1992)
- Dysregulation of diurnal rhythms of serotonin 5-HT2C and corticosteroid receptor gene expression in the hippocampus with food restriction and glucocorticoids. Holmes, M.C., French, K.L., Seckl, J.R. J. Neurosci. (1997)
- The effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive shock. Heal, D.J., Smith, S.L. Neuropharmacology (1988)
- Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. Gleason, S.D., Shannon, H.E. Eur. J. Pharmacol. (1998)
- Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations. Costall, B., Naylor, R.J. Br. J. Pharmacol. (1995)
- Effect of minaprine on cycloheximide-induced amnesia in mice. Nabeshima, T., Kawashima, K., Kameyama, T. Eur. J. Pharmacol. (1989)
- 5-HT1A agonists modulate mouse antipredator defensive behavior differently from the 5-HT2A antagonist pirenperone. Griebel, G., Blanchard, D.C., Jung, A., Masuda, C.K., Blanchard, R.J. Pharmacol. Biochem. Behav. (1995)
- Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Goodwin, G.M., De Souza, R.J., Green, A.R. Nature (1985)
- Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. McGraw, D.W., Almoosa, K.F., Paul, R.J., Kobilka, B.K., Liggett, S.B. J. Clin. Invest. (2003)
- Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Zhao, A., Urban, J.F., Morimoto, M., Elfrey, J.E., Madden, K.B., Finkelman, F.D., Shea-Donohue, T. Gastroenterology (2006)
- Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Walterscheid, J.P., Nghiem, D.X., Kazimi, N., Nutt, L.K., McConkey, D.J., Norval, M., Ullrich, S.E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- DARPP-32 mediates serotonergic neurotransmission in the forebrain. Svenningsson, P., Tzavara, E.T., Liu, F., Fienberg, A.A., Nomikos, G.G., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Kaur, G., Kulkarni, S.K. Prog. Neuropsychopharmacol. Biol. Psychiatry (2002)
- Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells. Sullivan, N.R., Burke, T., Siafaka-Kapadai, A., Javors, M., Hensler, J.G. J. Neurochem. (2004)
- 5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice. Goodwin, G.M., Green, A.R., Johnson, P. Br. J. Pharmacol. (1984)
- Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors. Matsuno, K., Senda, T., Matsunaga, K., Mita, S., Kaneto, H. Psychopharmacology (Berl.) (1993)
- Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14. Rasmussen, E., Cipp, L., Hitzemann, R. J. Pharmacol. Exp. Ther. (1999)
- The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Hsieh, C.L., Bowcock, A.M., Farrer, L.A., Hebert, J.M., Huang, K.N., Cavalli-Sforza, L.L., Julius, D., Francke, U. Somat. Cell Mol. Genet. (1990)
- Antisense inhibition of 5-hydroxytryptamine2a receptor induces an antidepressant-like effect in mice. Sibille, E., Sarnyai, Z., Benjamin, D., Gal, J., Baker, H., Toth, M. Mol. Pharmacol. (1997)
- A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. Kurrasch-Orbaugh, D.M., Parrish, J.C., Watts, V.J., Nichols, D.E. J. Neurochem. (2003)
- In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice. Rueter, L.E., Tecott, L.H., Blier, P. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. Amargós-Bosch, M., Bortolozzi, A., Puig, M.V., Serrats, J., Adell, A., Celada, P., Toth, M., Mengod, G., Artigas, F. Cereb. Cortex (2004)
- Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists. Sternberg, E.M., Trial, J., Parker, C.W. J. Immunol. (1986)
- Different role of 5-HT1A and 5-HT2 receptors in spinal cord in the control of nociceptive responsiveness. Eide, P.K., Hole, K. Neuropharmacology (1991)
- New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Frankel, W.N., Valenzuela, A., Lutz, C.M., Johnson, E.W., Dietrich, W.F., Coffin, J.M. Mamm. Genome (1995)
- 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Choi, D.S., Ward, S.J., Messaddeq, N., Launay, J.M., Maroteaux, L. Development (1997)
- The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Goodwin, G.M., De Souza, R.J., Green, A.R. Psychopharmacology (Berl.) (1986)
- Implication of 5-HT2 receptor subtypes in the mechanism of action of antidepressants in the four plates test. Nic Dhonnchadha, B.A., Ripoll, N., Clénet, F., Hascoët, M., Bourin, M. Psychopharmacology (Berl.) (2005)
- Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor. Yang, M., Srikiatkhachorn, A., Anthony, M., Chong, B.H. Blood Coagul. Fibrinolysis (1996)
- Transcriptional control of the rat serotonin-2 receptor gene. Garlow, S.J., Ciaranello, R.D. Brain Res. Mol. Brain Res. (1995)
- Role of the inhibitory adrenergic alpha 2 and serotonergic 5-HT1A components of cocaine's actions on the DOI-induced head-twitch response in 5-HT2-receptor supersensitive mice. Darmani, N.A. Pharmacol. Biochem. Behav. (1993)
- Peripherally administered serotonin induces hyperglucagonemia in mice. Yamada, J., Sugimoto, Y., Kimura, I., Watanabe, Y., Takeuchi, N., Horisaka, K. Life Sci. (1993)
- NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in mice. Kim, H.S., Park, I.S., Park, W.K. Life Sci. (1998)
- 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. Martin, J.R., Bös, M., Jenck, F., Moreau, J., Mutel, V., Sleight, A.J., Wichmann, J., Andrews, J.S., Berendsen, H.H., Broekkamp, C.L., Ruigt, G.S., Köhler, C., Delft, A.M. J. Pharmacol. Exp. Ther. (1998)
- Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice. Pietrovski, E.F., Rosa, K.A., Facundo, V.A., Rios, K., Marques, M.C., Santos, A.R. Pharmacol. Biochem. Behav. (2006)
- Serotonin receptors and animal models of aggressive behavior. Olivier, B., Mos, J., van Oorschot, R., Hen, R. Pharmacopsychiatry (1995)
- Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. Dumuis, A., Sebben, M., Bockaert, J. Mol. Pharmacol. (1988)
- Differential effects of novel ligands for 5-HT receptor subtypes on nonopioid defensive analgesia in male mice. Rodgers, R.J., Shepherd, J.K., Donát, P. Neuroscience and biobehavioral reviews. (1991)
- A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. Xia, Z., Gray, J.A., Compton-Toth, B.A., Roth, B.L. J. Biol. Chem. (2003)
- Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. Doble, A., Girdlestone, D., Piot, O., Allam, D., Betschart, J., Boireau, A., Dupuy, A., Guérémy, C., Ménager, J., Zundel, J.L. Br. J. Pharmacol. (1992)