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Chemical Compound Review:

AZOMETHANE dimethyldiazene

Synonyms: AG-F-69094, AC1Q4TCX, CTK1D3851, CTK1D5815, CTK3I9351, ...

Kari, F.W. et al., Lijinsky, W., Fernandes, R.X. et al.

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High impact information on dimethyldiazene

The percentage of administered [14C]DMH expired as azomethane varied inversely with dietary protein concentration, while AOM-induced host-mediated mutagenesis was directly proportional to dietary protein (p less than 0.01) [1].
Methyl radicals were generated by laser flash photolysis of azomethane or acetone [2].
These require metabolic activation, as do 1,2-dimethylhydrazine, azomethane, and azoxymethane, another group of colon carcinogens [3].

References

Effect of dietary protein concentration on yield of mutagenic metabolites from 1,2-dimethylhydrazine in mice. Kari, F.W., Johnston, J.B., Truex, C.R., Visek, W.J. Cancer Res. (1983) [Pubmed]
Falloff curves for the Reaction CH3 + O2 (+ M) --> CH3O2 (+ M) in the pressure range 2-1000 bar and the temperature range 300-700 K. Fernandes, R.X., Luther, K., Troe, J. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
Intestinal cancer induced by N-nitroso compounds. Lijinsky, W. Toxicologic pathology. (1988) [Pubmed]

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