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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Photolysis


Psychiatry related information on Photolysis


High impact information on Photolysis

  • Here we report that paroxysmal depolarization shifts can be initiated by release of glutamate from extrasynaptic sources or by photolysis of caged Ca(2+) in astrocytes [7].
  • Here we report a laboratory demonstration that glycine, alanine and serine naturally form from ultraviolet photolysis of the analogues of icy interstellar grains [8].
  • Analyses of water extracts indicate that extraterrestrial processes including photolysis and formaldehyde chemistry could account for the observed compounds [9].
  • We show that photolysis of Fe(III)-siderophore complexes leads to the formation of lower-affinity Fe(III) ligands and the reduction of Fe(III), increasing the availability of siderophore-bound iron for uptake by planktonic assemblages [10].
  • Here we present measurements of sulphur isotopes in oxidized and reduced phases from the SNC meteorites--the group of related achondrite meteorites believed to have originated on Mars--together with the results of laboratory photolysis studies of two important martian atmospheric sulphur species (SO2 and H2S) [11].

Chemical compound and disease context of Photolysis


Biological context of Photolysis


Anatomical context of Photolysis


Associations of Photolysis with chemical compounds


Gene context of Photolysis

  • Under mild conditions, photolysis yielded highly reactive carbenes, responsible for the formation of covalent bonds to the CRF receptor [31].
  • Previous studies have shown that the expression of YHB1 is optimal under normoxic or hyperoxic conditions, yet respiring yeast cells have low levels of reduced YHb pigment as detected by carbon monoxide (CO) photolysis difference spectroscopy of glucose-reduced cells [32].
  • Picosecond time-resolved resonance Raman (ps-TR3) spectroscopy of transient five-coordinate heme species produced by the photolysis of carbon monoxide (CO) adducts of Cgb and Ngb showed Fe-His stretching (nu(Fe-His)) bands at 229 and 221 cm(-1), respectively [33].
  • RESULTS: One hour of UVA photolysis of human lens resulted in a 70% loss in glutathione reductase (GR)-specific activity and a 24% loss in glyceraldehyde-3-phosphate dehydrogenase (G3PD)-specific activity [34].
  • Without photolysis, lapachenole is a substrate of CYP3A4 and can be metabolized to hydroxylated products by this enzyme [35].

Analytical, diagnostic and therapeutic context of Photolysis

  • Thapsigargin incubation, microinjection of the Ca2+ chelator BAPTA, and photolysis of the Ca2+ cage NP-EGTA demonstrate that a Ca2+ elevation in astrocytes is both necessary and sufficient to modulate spontaneous transmitter release [36].
  • In this study we investigated physicochemical characteristics of the curcumin radical by pulse radiolysis and laser flash photolysis [37].
  • Biphasic geminate rebinding of CO to myoglobin upon flash photolysis has been associated to ligand distribution in hydrophobic cavities, structurally detected by time-resolved crystallography, xenon occupancy, and molecular simulations [38].
  • Reactions of nitrogen oxides with heme models. Characterization of NO and NO2 dissociation from Fe(TPP)(NO2)(NO) by flash photolysis and rapid dilution techniques: Fe(TPP)(NO2) as an unstable intermediate [39].
  • A lag period was also observed when ICa was stimulated by flash photolysis of caged GTP gamma S and when adenylyl cyclase was activated directly by rapid perfusion with forskolin [40].


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  15. Type I and type II photosensitization by the antibacterial drug nalidixic acid. A laser flash photolysis study. Vermeersch, G., Ronfard-Haret, J.C., Bazin, M., Carillet, V., Morliere, P., Santus, R. Photochem. Photobiol. (1991) [Pubmed]
  16. Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32. Fry, T., Evans, J.H., Sanderson, M.J. Microsc. Res. Tech. (2001) [Pubmed]
  17. Calcium-dependent immediate feedback control of inositol 1,4,5-triphosphate-induced Ca2+ release. Iino, M., Endo, M. Nature (1992) [Pubmed]
  18. Mechanism of odorant adaptation in the olfactory receptor cell. Kurahashi, T., Menini, A. Nature (1997) [Pubmed]
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  21. Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells. Ashery, U., Varoqueaux, F., Voets, T., Betz, A., Thakur, P., Koch, H., Neher, E., Brose, N., Rettig, J. EMBO J. (2000) [Pubmed]
  22. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Finch, E.A., Augustine, G.J. Nature (1998) [Pubmed]
  23. Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. Walker, J.W., Somlyo, A.V., Goldman, Y.E., Somlyo, A.P., Trentham, D.R. Nature (1987) [Pubmed]
  24. External Na dependence of ouabain-sensitive ATP:ADP exchange initiated by photolysis of intracellular caged-ATP in human red cell ghosts. Kaplan, J.H., Hollis, R.J. Nature (1980) [Pubmed]
  25. Confocal imaging and local photolysis of caged compounds: dual probes of synaptic function. Wang, S.S., Augustine, G.J. Neuron (1995) [Pubmed]
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  27. Relaxation of muscle fibres by photolysis of caged ATP. Goldman, Y.E., Hibberd, M.G., McCray, J.A., Trentham, D.R. Nature (1982) [Pubmed]
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  29. Biogenic methane, hydrogen escape, and the irreversible oxidation of early Earth. Catling, D.C., Zahnle, K.J., McKay, C. Science (2001) [Pubmed]
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  31. Synthesis and characterization of a photoactivatable analog of corticotropin-releasing factor for specific receptor labeling. Rühmann, A., Köpke, A.K., Dautzenberg, F.M., Spiess, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. Cassanova, N., O'Brien, K.M., Stahl, B.T., McClure, T., Poyton, R.O. J. Biol. Chem. (2005) [Pubmed]
  33. Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Sawai, H., Makino, M., Mizutani, Y., Ohta, T., Sugimoto, H., Uno, T., Kawada, N., Yoshizato, K., Kitagawa, T., Shiro, Y. Biochemistry (2005) [Pubmed]
  34. Effect of UVA light on the activity of several aged human lens enzymes. Linetsky, M., Chemoganskiy, V.G., Hu, F., Ortwerth, B.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  35. Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry. Wen, B., Doneanu, C.E., Gartner, C.A., Roberts, A.G., Atkins, W.M., Nelson, S.D. Biochemistry (2005) [Pubmed]
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  39. Reactions of nitrogen oxides with heme models. Characterization of NO and NO2 dissociation from Fe(TPP)(NO2)(NO) by flash photolysis and rapid dilution techniques: Fe(TPP)(NO2) as an unstable intermediate. Lim, M.D., Lorkovic, I.M., Wedeking, K., Zanella, A.W., Works, C.F., Massick, S.M., Ford, P.C. J. Am. Chem. Soc. (2002) [Pubmed]
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