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Chemical Compound Review

AZOXYMETHANE     methyl-methylimino-oxido- azanium

Synonyms: CCRIS 67, AG-E-79959, A2853_SIGMA, LS-1087, NSC-171779, ...
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Disease relevance of AZOXYMETHANE


Psychiatry related information on AZOXYMETHANE


High impact information on AZOXYMETHANE

  • Two weeks later, 30 animals in each group received a subcutaneous injection of azoxymethane (15 mg/kg body weight); 1 week later, they received a second injection [7].
  • PURPOSE: The purpose of this study was twofold: 1) to investigate the activity of N-myristoyltransferase in azoxymethane-induced rat colonic cancer tissue compared with normal and normal-appearing rat colonic tissue and 2) to determine if similar differences would be observed in a small sample of human colonic tumors [8].
  • Continuous oral administration of DFMO at 1% (approximately 8 mg/g body wt/wk) and 0.25% (approximately 2 mg/g body wt/wk) produced 93% inhibition of ODC induction by AOM in the right and left colons throughout the study [9].
  • Interactions of selenium deficiency, vitamin E, polyunsaturated fat, and saturated fat on azoxymethane-induced colon carcinogenesis in male F344 rats [10].
  • The clonal composition of neoplastic foci was examined in histological sections of the colonic epithelium of azoxymethane (CAS: 25843-45-2)-treated CBA/Ca----C57BL/6J mouse aggregation chimeras, with the use of H-2 antigens as markers of cellular genotype [11].

Chemical compound and disease context of AZOXYMETHANE


Biological context of AZOXYMETHANE


Anatomical context of AZOXYMETHANE

  • The transmission electron microscopic features of grossly normal colonic mucosa in the azoxymethane [(AOM) CAS: 25843-45-2]-treated rat model of colonic carcinogenesis were studied by the method of concomitant variation [22].
  • Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats [23].
  • Fatty acid content in the feces increased in the animals on the fat diet but was not affected by azoxymethane [24].
  • Further analysis of ras-p21 levels in cytosol and plasma membrane revealed that feeding a HFFO diet resulted in increasing accumulation of ras-p21 in cytoplasm with a concomitant decrease in membrane-bound ras-p21 levels as observed in animals sacrificed 12 and 36 weeks after the last AOM injection [25].
  • We compared the metabolism of azoxymethane (AOM) and of N-nitrosodimethylamine (NDMA) by liver microsomes obtained from male F344 rats pair-fed for 3 weeks either a control liquid diet or an isocaloric liquid diet containing ethanol at a concentration of 6.6% by volume [26].

Associations of AZOXYMETHANE with other chemical compounds


Gene context of AZOXYMETHANE

  • The present study was undertaken to determine if there is differential expression of COX in colonic tumors in azoxymethane-treated rats [17].
  • CONCLUSIONS: These results indicate that COX-2 is expressed very early in the pathogenesis of colitis-associated tumors, and that the expression pattern is similar to that seen in tumors from azoxymethane-treated and Min/+ mice [31].
  • Administration of 250, 500, or 1000 ppm of a novel selective EP1 antagonist, ONO-8711, in the diet to azoxymethane-treated C57BL/6J mice also resulted in a dose-dependent reduction of ACF formation [32].
  • By mating Fabpl(4xat-132) Cre mice with Tgfbr2(flx/flx) mice, we have generated a mouse model that is null for Tgfbr2 in the colonic epithelium, and in this model system, we have assessed the effect of loss of TGF-beta signaling in vivo on colon cancer formation induced by azoxymethane (AOM) [21].
  • METHODS: Heterozygous Cdx2(+/-) mice were analysed for spontaneous malignant tumours and for tumour development after treatment with a DNA mutagen, azoxymethane [33].

Analytical, diagnostic and therapeutic context of AZOXYMETHANE


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  2. Effect of a chemically defined diet in liquid form on colon carcinogenesis in rats. Tatsuta, M., Yamamura, H., Iishi, H., Ichii, M., Noguchi, S., Baba, M., Taniguchi, H. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Combined inhibitors of carcinogenesis: effect on azoxymethane-induced intestinal cancer in rats. Nigro, N.D., Bull, A.W., Wilson, P.S., Soullier, B.K., Alousi, M.A. J. Natl. Cancer Inst. (1982) [Pubmed]
  4. Large intestinal carcinogenesis. II. Histogenesis and unusual features of low-dose azoxymethane-induced carcinomas in F344 rats. Shamsuddin, A.M., Hogan, M.L. J. Natl. Cancer Inst. (1984) [Pubmed]
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  7. Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets. Reddy, B.S., Rivenson, A., El-Bayoumy, K., Upadhyaya, P., Pittman, B., Rao, C.V. J. Natl. Cancer Inst. (1997) [Pubmed]
  8. Increased N-myristoyltransferase activity observed in rat and human colonic tumors. Magnuson, B.A., Raju, R.V., Moyana, T.N., Sharma, R.K. J. Natl. Cancer Inst. (1995) [Pubmed]
  9. Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis. Luk, G.D., Zhang, S.Z., Hamilton, S.R. J. Natl. Cancer Inst. (1989) [Pubmed]
  10. Interactions of selenium deficiency, vitamin E, polyunsaturated fat, and saturated fat on azoxymethane-induced colon carcinogenesis in male F344 rats. Reddy, B.S., Tanaka, T. J. Natl. Cancer Inst. (1986) [Pubmed]
  11. Direct examination of the clonality of carcinogen-induced colonic epithelial dysplasia in chimeric mice. Ponder, B.A., Wilkinson, M.M. J. Natl. Cancer Inst. (1986) [Pubmed]
  12. Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. Watanabe, K., Reddy, B.S., Weisburger, J.H., Kritchevsky, D. J. Natl. Cancer Inst. (1979) [Pubmed]
  13. Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane. Reddy, B.S., Narisawa, T., Weisburger, J.H. Cancer Res. (1976) [Pubmed]
  14. Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes. Tanaka, T., Kawabata, K., Kakumoto, M., Hara, A., Murakami, A., Kuki, W., Takahashi, Y., Yonei, H., Maeda, M., Ota, T., Odashima, S., Yamane, T., Koshimizu, K., Ohigashi, H. Cancer Res. (1998) [Pubmed]
  15. Polyethylene-glycol suppresses colon cancer and causes dose-dependent regression of azoxymethane-induced aberrant crypt foci in rats. Parnaud, G., Taché, S., Peiffer, G., Corpet, D.E. Cancer Res. (1999) [Pubmed]
  16. Evaluation of dietary dehydroepiandrosterone for chemoprotection against tumorigenesis in premalignant colonic epithelium of male F344 rats. Hamilton, S.R., Gordon, G.B., Floyd, J., Golightly, S. Cancer Res. (1991) [Pubmed]
  17. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. DuBois, R.N., Radhika, A., Reddy, B.S., Entingh, A.J. Gastroenterology (1996) [Pubmed]
  18. Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Baek, S.J., Okazaki, R., Lee, S.H., Martinez, J., Kim, J.S., Yamaguchi, K., Mishina, Y., Martin, D.W., Shoieb, A., McEntee, M.F., Eling, T.E. Gastroenterology (2006) [Pubmed]
  19. Characterization of bile salt-induced apoptosis in colon cancer cell lines. Schlottman, K., Wachs, F.P., Krieg, R.C., Kullmann, F., Schölmerich, J., Rogler, G. Cancer Res. (2000) [Pubmed]
  20. Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats. Kawamori, T., Tanaka, T., Ohnishi, M., Hirose, Y., Nakamura, Y., Satoh, K., Hara, A., Mori, H. Cancer Res. (1995) [Pubmed]
  21. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Biswas, S., Chytil, A., Washington, K., Romero-Gallo, J., Gorska, A.E., Wirth, P.S., Gautam, S., Moses, H.L., Grady, W.M. Cancer Res. (2004) [Pubmed]
  22. Effects of carcinogen dosage on experimental colonic carcinogenesis by azoxymethane: an ultrastructural study of grossly normal colonic mucosa. Pan, Q., Hamilton, S.R., Hyland, J., Boitnott, J.K. J. Natl. Cancer Inst. (1985) [Pubmed]
  23. Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats. Shamsuddin, A.K., Trump, B.F. J. Natl. Cancer Inst. (1981) [Pubmed]
  24. Effect of diet high in beef fat on the composition of fecal bile acids during intestinal carcinogenesis in the rat. Nigro, N.D., Campbell, R.L., Singh, D.V., Lin, Y.N. J. Natl. Cancer Inst. (1976) [Pubmed]
  25. Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer. Singh, J., Hamid, R., Reddy, B.S. Cancer Res. (1997) [Pubmed]
  26. Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: similarity to the microsomal metabolism of N-nitrosodimethylamine. Sohn, O.S., Fiala, E.S., Puz, C., Hamilton, S.R., Williams, G.M. Cancer Res. (1987) [Pubmed]
  27. Effect of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats. Nigro, N.D., Bull, A.W., Klopfer, B.A., Pak, M.S., Campbell, R.L. J. Natl. Cancer Inst. (1979) [Pubmed]
  28. Effect of neomycin on azoxymethane-induced colon carcinogenesis in F344 rats. Reddy, B.S., Furuya, K., Lowenfels, A. J. Natl. Cancer Inst. (1984) [Pubmed]
  29. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Myung, S.J., Rerko, R.M., Yan, M., Platzer, P., Guda, K., Dotson, A., Lawrence, E., Dannenberg, A.J., Lovgren, A.K., Luo, G., Pretlow, T.P., Newman, R.A., Willis, J., Dawson, D., Markowitz, S.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Rao, C.V., Rivenson, A., Simi, B., Reddy, B.S. Cancer Res. (1995) [Pubmed]
  31. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Shattuck-Brandt, R.L., Varilek, G.W., Radhika, A., Yang, F., Washington, M.K., DuBois, R.N. Gastroenterology (2000) [Pubmed]
  32. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Watanabe, K., Kawamori, T., Nakatsugi, S., Ohta, T., Ohuchida, S., Yamamoto, H., Maruyama, T., Kondo, K., Ushikubi, F., Narumiya, S., Sugimura, T., Wakabayashi, K. Cancer Res. (1999) [Pubmed]
  33. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M.P., Kedinger, M., Beck, F., Freund, J.N., Domon-Dell, C. Gut (2003) [Pubmed]
  34. Effect of dietary beef fat on intestinal tumor formation by azoxymethane in rats. Nigro, N.D., Singh, D.V., Campbell, R.L., Sook, M. J. Natl. Cancer Inst. (1975) [Pubmed]
  35. Large intestinal carcinogenesis. III. Studies in low-incidence (Japanese) patients. Shamsuddin, A.M., Kato, Y., Sugano, H. J. Natl. Cancer Inst. (1984) [Pubmed]
  36. Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats. Bristol, J.B., Ghatei, M.A., Smith, J.H., Bloom, S.R., Williamson, R.C. Gastroenterology (1987) [Pubmed]
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  38. Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure. Doering, C.B., Josephson, C.D., Craddock, H.N., Lollar, P. Blood (2002) [Pubmed]
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