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Chemical Compound Review:

CCRIS 2587 1-nitro-8-nitroso-pyrene

Synonyms: AG-D-06003, ACMC-20m3o9, CTK3J9108, LS-129454, AC1L33BT, ...

Lambert, I.B. et al., Lambert, I.B. et al., Norman, C.A. et al., Lambert, I.B. et al.

Lambert, Carroll, Laycock, Koziarz, Lawford, Duval, Turner, Booth, Douville, Whiteway, Nokhbeh,

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Disease relevance of CCRIS 2587

The action of 1-nitroso-8-nitropyrene in Escherichia coli: DNA adduct formation and mutational consequences in the absence of nucleotide excision-repair [1].

High impact information on CCRIS 2587

We have examined the mutational specificity of 1-nitroso-8-nitropyrene (1,8-NONP), an activated metabolite of the carcinogen 1,8-dinitropyrene, in the lacI gene of Escherichia coli strains which differ with respect to nucleotide excision repair (+/- delta uvrB) and MucA/B-mediated error-prone translesion synthesis (+/- pKM101) [2].
The influence of local DNA sequence and DNA repair background on the mutational specificity of 1-nitroso-8-nitropyrene in Escherichia coli: inferences for mutagenic mechanisms [2].
Formation of DNA adducts, following treatment of primary rabbit tracheal epithelial cells (RTEC) with 1,8-dinitropyrene (1,8-DNP) and its partially reduced derivative, 1-nitro-8-nitrosopyrene (1,8-NONO2), was examined using the 32P-post-labelling technique [3].

Chemical compound and disease context of CCRIS 2587

To study the mechanisms of mutagenesis by the carcinogen 1,8-dinitropyrene we have determined the DNA adducts formed and mutations induced by its partially activated metabolite 1-nitroso-8-nitropyrene (1,8-NONP) in an Escherichia coli strain deficient in nucleotide excision-repair [1].
Cellular determinants of the mutational specificity of 1-nitroso-6-nitropyrene and 1-nitroso-8-nitropyrene in the lacI gene of Escherichia coli [4].

References

The action of 1-nitroso-8-nitropyrene in Escherichia coli: DNA adduct formation and mutational consequences in the absence of nucleotide excision-repair. Lambert, I.B., Gordon, A.J., Bryant, D.W., Glickman, B.W., McCalla, D.R. Carcinogenesis (1991) [Pubmed]
The influence of local DNA sequence and DNA repair background on the mutational specificity of 1-nitroso-8-nitropyrene in Escherichia coli: inferences for mutagenic mechanisms. Lambert, I.B., Gordon, A.J., Glickman, B.W., McCalla, D.R. Genetics (1992) [Pubmed]
DNA adduct formation in primary rabbit tracheal epithelial cells following treatment with 1,8-dinitropyrene and its partially reduced derivative, 1-nitro-8-nitrosopyrene. Norman, C.A., Lambert, I.B., Davison, L.M., Bryant, D.W., McCalla, D.R. Carcinogenesis (1989) [Pubmed]
Cellular determinants of the mutational specificity of 1-nitroso-6-nitropyrene and 1-nitroso-8-nitropyrene in the lacI gene of Escherichia coli. Lambert, I.B., Carroll, C., Laycock, N., Koziarz, J., Lawford, I., Duval, L., Turner, G., Booth, R., Douville, S., Whiteway, J., Nokhbeh, M.R. Mutat. Res. (2001) [Pubmed]

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