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Chemical Compound Review:

NSC-444 N-(4-chlorophenyl)ethanamide

Synonyms: CHEMBL15991, AGN-PC-00GTHN, NSC444, SureCN197282, ACMC-209las, ...

Ali, M.S. et al., Walton, J.D. et al., Ehlhardt, W.J. et al.

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High impact information on NSC444

[3H]Saf binding is inhibited by 4 chloroacetanilide herbicides with IC50 values of 0.07 to 0.48 microM and by 12 thiocarbamate herbicides and analogs with IC50 values of 0.06 to 2.3 microM [1].
The appearance of p-chloroacetanilide along with p-chloroaniline in plasma after an oral dose of [14C]p-chloroaniline also was studied in rhesus monkey [2].
Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography [3].

References

Specific binding of a dichloroacetamide herbicide safener in maize at a site that also binds thiocarbamate and chloroacetanilide herbicides. Walton, J.D., Casida, J.E. Plant Physiol. (1995) [Pubmed]
Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey. Ehlhardt, W.J., Howbert, J.J. Drug Metab. Dispos. (1991) [Pubmed]
Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography. Ali, M.S., Rafiuddin, S., Ghori, M., Kahtri, A.R. Journal of AOAC International (2007) [Pubmed]

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