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Chemical Compound Review:

ISOVALERAMIDE 3-methylbutanamide

Synonyms: Isopentanamide, CHEMBL171066, NPS-1776, ACMC-1B212, AG-F-87157, ...

Isoherranen, N. et al., Eadie, M.J.

Eadie,

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High impact information on Isovaleric amide

SUMMARY: At present there are three compounds in clinical trials in patients with epilepsy that can be regarded as second-generation VPA: valproyl glycinamide, 3-methylbutanamide or isovaleramide and SPD421 (DP-VPA) [1].
Valerian preparations yield isovaleric acid, a substance analogous to valproic acid and likely to possess anticonvulsant properties, as isovaleramide does [2].

References

New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? Isoherranen, N., Yagen, B., Bialer, M. Curr. Opin. Neurol. (2003) [Pubmed]
Could valerian have been the first anticonvulsant? Eadie, M.J. Epilepsia (2004) [Pubmed]

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