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Chemical Compound Review:

Poldine (1,1-dimethyl-2,3,4,5- tetrahydropyrrol-2...

Synonyms: SureCN1641786, AC1L1WGB, AC1Q65V6, 596-50-9, UNII-8R92106W2F

Bieberdorf, F.A. et al., Saunders, J.H. et al., Hill, B.H.

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Disease relevance of Poldine

Effects of cimetidine and poldine on nocturnal gastric secretion in duodenal ulcer [1].
Poldine iontophoresis in the treatment of palmar and plantar hyperhidrosis [2].

High impact information on Poldine

Effect of optimum therapeutic dose of poldine on acid secretion, gastric acidity, gastric emptying, and serum gastrin concentration after a protein meal [3].

Analytical, diagnostic and therapeutic context of Poldine

Poldine had no consistent effect on serum gastrin concentration after the meal when pH was maintained at a constant level by titration with bicarbonate; therefore, poldine inhibition of acid secretion is not mediated by a reduction of serum gastrin concentration [3].

References

Effects of cimetidine and poldine on nocturnal gastric secretion in duodenal ulcer. Saunders, J.H., Cargill, J.M., Wormsley, K.G. Digestion (1977) [Pubmed]
Poldine iontophoresis in the treatment of palmar and plantar hyperhidrosis. Hill, B.H. Australas. J. Dermatol. (1976) [Pubmed]
Effect of optimum therapeutic dose of poldine on acid secretion, gastric acidity, gastric emptying, and serum gastrin concentration after a protein meal. Bieberdorf, F.A., Walsh, J.H., Fordtran, J.S. Gastroenterology (1975) [Pubmed]

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