Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

p-HYDROXYNOREPHEDRINE 4-(2-amino-1-hydroxy- propyl)phenol

Synonyms: SureCN723104, AKOS009031521, AC1L1WM5, 552-85-2, 771-91-5, ...

Freeman, J.J. et al., Simpson, L.L., Arai, Y. et al.

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High impact information on p-HYDROXYNOREPHEDRINE

Two amphetamine metabolites, p-hydroxyamphetamine (p-OHA) and p-hydroxynorephedrine (p-OHN), selectively inhibited the A form of monoamine oxidase (MAO) in rat and mouse forebrain homogenates [1].
Blood pressure and heart rate response evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine II. A quantitative assessment of the role of amphetamine metabolites in acute responses evoked by d-amphetamine [2].
Since both tricyclic drugs inhibit the aromatic hydroxylation of amphetamine, these studies do not support the hypothesis that hydroxylated metabolites of amphetamine, p-hydroxyamphetamine and p-hydroxynorephedrine are essential for the peripheral sympathomimetic effects of amphetamine [3].

References

Inhibition of brain type A monoamine oxidase and 5-hydroxytryptamine uptake by two amphetamine metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine. Arai, Y., Kim, S.K., Kinemuchi, H., Tadano, T., Satoh, S.E., Satoh, N., Kisara, K. J. Neurochem. (1990) [Pubmed]
Blood pressure and heart rate response evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine II. A quantitative assessment of the role of amphetamine metabolites in acute responses evoked by d-amphetamine. Simpson, L.L. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
The role of p-hydroxylation of amphetamine in its peripheral mode of action. Freeman, J.J., Sulser, F. J. Pharm. Pharmacol. (1975) [Pubmed]

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