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Chemical Compound Review:

AG-K-49560 2-hydroxy-3-oxo-propanoic acid

Synonyms: CHEBI:16992, HMDB06938, AC1L1ARW, AC1Q6PMY, CTK4F4432, ...

Njau, R.K. et al., Chang, Y.Y. et al., Fiehn, O. et al., de Windt, F.E. et al.

Fiehn, Kopka, Trethewey, Willmitzer,

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Disease relevance of C01146

Glyoxylate carboligase (Gcl) (EC 4.1.1.47) of Escherichia coli catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde, a key intermediate in glyoxylate catabolism [1].

High impact information on C01146

The purified recombinant protein very specifically catalyzed the NAD(+)-dependent oxidation of d-glycerate and the NADH-dependent reduction of tartronate semialdehyde, identifying this protein as a tartronate semialdehyde reductase [2].
More than 15 uncommon plant metabolites were identified, some of which are novel in Arabidopsis, such as tartronate semialdehyde, citramalic acid, allothreonine, or glycolic amide [3].
The equilibrium constant K = [tartronate semialdehyde] divided by [hydroxypyruvate] was found to be 2.5 at pH 7.1, and 30 degrees C [4].

References

Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family. Chang, Y.Y., Wang, A.Y., Cronan, J.E. J. Biol. Chem. (1993) [Pubmed]
Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae. Njau, R.K., Herndon, C.A., Hawes, J.W. J. Biol. Chem. (2000) [Pubmed]
Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Fiehn, O., Kopka, J., Trethewey, R.N., Willmitzer, L. Anal. Chem. (2000) [Pubmed]
Purification and some properties of hydroxypyruvate isomerase of Bacillus fastidiosus. de Windt, F.E., van der Drift, C. Biochim. Biophys. Acta (1980) [Pubmed]

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