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Chemical Compound Review

glycerate     (2R)-2,3-dihydroxypropanoic acid

Synonyms: CHEBI:32398, HMDB00139, FT-0605161, AC1L96UT, C00258, ...
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Disease relevance of GLYCERIC ACID


High impact information on GLYCERIC ACID


Chemical compound and disease context of GLYCERIC ACID


Biological context of GLYCERIC ACID


Anatomical context of GLYCERIC ACID

  • Fructose 2,6-bisphosphate in rat erythrocytes. Inhibition of fructose 2,6-bisphosphate synthesis and measurement by glycerate 2,3-bisphosphate [18].
  • Not only with intact but also with osmotically shocked peroxisomes, which had retained the aggregated state of the peroxisomal matrix but lost the integrity of the boundary membrane, the rates of glycerate synthesis were as high as required for the photorespiratory cycle in vivo [19].
  • Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord [20].
  • Glycerate 2,3-P2 increased the Mg2+ optimum for protein synthesis by chelation of Mg2+, but Mg2+ addition did not completely reverse the inhibition, suggesting an additional site of action. eIF-2 has been used to examine the activity of casein kinase II in reticulocyte lysates in response to glycerate 2,3-P2 [21].
  • Synthesis of glucose from 10 mM D-glycerate by hepatocytes isolated from rats fasted 24 h was inhibited by 3-aminopicolinate (3AP), 3-mercaptopicolinate (3MP), and aminoxyacetate (AOA) [22].

Associations of GLYCERIC ACID with other chemical compounds


Gene context of GLYCERIC ACID


Analytical, diagnostic and therapeutic context of GLYCERIC ACID


  1. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Cramer, S.D., Ferree, P.M., Lin, K., Milliner, D.S., Holmes, R.P. Hum. Mol. Genet. (1999) [Pubmed]
  2. Crystallization and preliminary diffraction studies of hydroxypyruvate reductase (D-glycerate dehydrogenase) from Hyphomicrobium methylovorum. Goldberg, J.D., Brick, P., Yoshida, T., Mitsunaga, T., Oshiro, T., Shimao, M., Izumi, Y. J. Mol. Biol. (1992) [Pubmed]
  3. The plant-like c2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria. Eisenhut, M., Kahlon, S., Hasse, D., Ewald, R., Lieman-Hurwitz, J., Ogawa, T., Ruth, W., Bauwe, H., Kaplan, A., Hagemann, M. Plant Physiol. (2006) [Pubmed]
  4. A compound representing the D-glycerate terminus of the methylglucose-containing polysaccharide of Mycobacterium smegmatis. Hunter, B.K., Mowbray, S.L., Walton, D.J. Biochemistry (1979) [Pubmed]
  5. D-GLYCERATE 3-KINASE, the last unknown enzyme in the photorespiratory cycle in Arabidopsis, belongs to a novel kinase family. Boldt, R., Edner, C., Kolukisaoglu, U., Hagemann, M., Weckwerth, W., Wienkoop, S., Morgenthal, K., Bauwe, H. Plant Cell (2005) [Pubmed]
  6. Functional homology of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphoglycerate mutase, and 2,3-bisphosphoglycerate mutase. Tauler, A., el-Maghrabi, M.R., Pilkis, S.J. J. Biol. Chem. (1987) [Pubmed]
  7. Glycerated hemoglobin, alpha 2A beta 2(82) (EF6) N epsilon-glyceryllysine. A new post-translational modification occurring in erythrocyte bisphosphoglyceromutase deficiency. Blouquit, Y., Rhoda, M.D., Delanoe-Garin, J., Rosa, R., Prome, J.C., Poyart, C., Puzo, G., Bernassau, J.M., Rosa, J. J. Biol. Chem. (1986) [Pubmed]
  8. Phenotypic expression of primary hyperoxaluria: comparative features of types I and II. Milliner, D.S., Wilson, D.M., Smith, L.H. Kidney Int. (2001) [Pubmed]
  9. Identification and mutation of a gene required for glycerate kinase activity from a facultative methylotroph, Methylobacterium extorquens AM1. Chistoserdova, L., Lidstrom, M.E. J. Bacteriol. (1997) [Pubmed]
  10. A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. Monterrubio, R., Baldoma, L., Obradors, N., Aguilar, J., Badia, J. J. Bacteriol. (2000) [Pubmed]
  11. Specific enzymatic assay for D-glucarate in human serum. Blumenthal, H.J., Lucuta, V.L., Blumenthal, D.C. Anal. Biochem. (1990) [Pubmed]
  12. Glyceraldehyde 3-p dehydrogenase, glycerate 3-P kinase and enolase mutants of Escherichia coli: genetic studies. Irani, M.H., Maitra, P.K. Mol. Gen. Genet. (1976) [Pubmed]
  13. Reaction intermediate partitioning by ribulose-bisphosphate carboxylases with differing substrate specificities. Pierce, J., Andrews, T.J., Lorimer, G.H. J. Biol. Chem. (1986) [Pubmed]
  14. Evidence for the two phosphate binding sites of an analogue of the thioacyl intermediate for the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction, from its crystal structure. Castilho, M.S., Pavão, F., Oliva, G., Ladame, S., Willson, M., Périé, J. Biochemistry (2003) [Pubmed]
  15. Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli. Cusa, E., Obradors, N., Baldomà, L., Badía, J., Aguilar, J. J. Bacteriol. (1999) [Pubmed]
  16. Influence of glycerate on photosynthesis by wheat chloroplasts. Edwards, G.E., Walker, D.A. Arch. Biochem. Biophys. (1984) [Pubmed]
  17. Metabolic flux analysis for serine alkaline protease fermentation by Bacillus licheniformis in a defined medium: effects of the oxygen transfer rate. Calik, P., Calik, G., TakaçS, n.u.l.l., Ozdamar, T.H. Biotechnol. Bioeng. (1999) [Pubmed]
  18. Fructose 2,6-bisphosphate in rat erythrocytes. Inhibition of fructose 2,6-bisphosphate synthesis and measurement by glycerate 2,3-bisphosphate. Sobrino, F., Rider, M.H., Gualberto, A., Hue, L. Biochem. J. (1987) [Pubmed]
  19. Protein organization in the matrix of leaf peroxisomes. A multi-enzyme complex involved in photorespiratory metabolism. Heupel, R., Heldt, H.W. Eur. J. Biochem. (1994) [Pubmed]
  20. Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord. Feld, R.D., Sallach, H.J. Arch. Biochem. Biophys. (1975) [Pubmed]
  21. 2,3-Bisphosphoglycerate inhibits hemoglobin synthesis and phosphorylation of initiation factor 2 by casein kinase II in reticulocyte lysates. Gonzatti, M.I., Traugh, J.A. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  22. Pathway of gluconeogenesis from D- and L-glycerate in rat hepatocytes. Chen, K.S., Lardy, H.A. Arch. Biochem. Biophys. (1988) [Pubmed]
  23. Structure of a novel phosphoglycolipid from Deinococcus radiodurans. Anderson, R., Hansen, K. J. Biol. Chem. (1985) [Pubmed]
  24. Crystal structure of a NAD-dependent D-glycerate dehydrogenase at 2.4 A resolution. Goldberg, J.D., Yoshida, T., Brick, P. J. Mol. Biol. (1994) [Pubmed]
  25. Transient increase in glucose 1,6-bisphosphate in human skeletal muscle during isometric contraction. Lee, A.D., Katz, A. Biochem. J. (1989) [Pubmed]
  26. Studies of the glycine metabolism in a patient with D-glyceric acidemia and hyperglycinemia. Kølvraa, S., Christensen, E., Brandt, N.J. Pediatr. Res. (1980) [Pubmed]
  27. Conversion of glycerate to serine in intact spinach leaf peroxisomes. Liang, Z., Yu, C., Huang, A.H. Arch. Biochem. Biophys. (1984) [Pubmed]
  28. Specificity of glucose 1,6-bisphosphate synthesis in rabbit skeletal muscle. Piatti, E., Accorsi, A., Piacentini, M.P., Fazi, A. Comp. Biochem. Physiol., B (1991) [Pubmed]
  29. Regulation of the human-erythrocyte hexose-monophosphate shunt under conditions of oxidative stress. A study using NMR spectroscopy, a kinetic isotope effect, a reconstituted system and computer simulation. Thorburn, D.R., Kuchel, P.W. Eur. J. Biochem. (1985) [Pubmed]
  30. Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. Schwarzenbacher, R., McMullan, D., Krishna, S.S., Xu, Q., Miller, M.D., Canaves, J.M., Elsliger, M.A., Floyd, R., Grzechnik, S.K., Jaroszewski, L., Klock, H.E., Koesema, E., Kovarik, J.S., Kreusch, A., Kuhn, P., McPhillips, T.M., Morse, A.T., Quijano, K., Spraggon, G., Stevens, R.C., van den Bedem, H., Wolf, G., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. Proteins (2006) [Pubmed]
  31. Further studies on the activity and subcellular distribution of alanine:glyoxylate aminotransferase in the livers of patients with primary hyperoxaluria type 1. Danpure, C.J., Jennings, P.R. Clin. Sci. (1988) [Pubmed]
  32. Biochemical contribution to diagnosis and study of a new case of D-glyceric acidemia/aciduria. Fontaine, M., Porchet, N., Largilliere, C., Marrakchi, S., Lhermitte, M., Aubert, J.P., Degand, P. Clin. Chem. (1989) [Pubmed]
  33. Mitochondrial and cytosolic localization of a single glycerate kinase in rat kidney cortex. Katayama, H., Kitagawa, Y., Sugimoto, E. J. Biochem. (1979) [Pubmed]
  34. Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems. Boyd, B.J., Whittaker, D.V., Khoo, S.M., Davey, G. International journal of pharmaceutics. (2006) [Pubmed]
  35. Specimen handling for the assay of adenylates and glycerate 2, 3-bisphosphate in erythrocytes. Ericson, A., De Verdier, C.H. Scand. J. Clin. Lab. Invest. (1981) [Pubmed]
  36. Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of glyceric acid in urine of patients with D-glyceric and L-glyceric acidurias. Rashed, M.S., Aboul-Enein, H.Y., AlAmoudi, M., Jakob, M., Al-Ahaideb, L.Y., Abbad, A., Shabib, S., Al-Jishi, E. Biomed. Chromatogr. (2002) [Pubmed]
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