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Chemical Compound Review:

b-BCH 6-aminobicyclo[2.2.1]heptane- 6-carboxylic...

Synonyms: AGN-PC-00OC60, SureCN202772, CHEMBL2074957, A7902_SIGMA, AC1L3GVN, ...

Salter, M. et al., Albrecht, J. et al., Awad, R. et al., Segel, G.B. et al., Blitzer, B.L. et al., et al.

Albrecht, Dolińska, Hilgier, Lipkowski, Nowacki,

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High impact information on 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid

Inhibition studies with a variety of substrates of various transport systems gave results consistent with aromatic amino acid transport being catalysed by two systems: a 2-aminobicyclo(2,2,1)heptane-2-carboxylic acid (BCH)-insensitive aromatic D- and L-amino acid-specific system, and the L-type system (BCH-sensitive) [1].
Methylaminoisobutyric acid (methyl-AIB) and 2-amino-2-carboxy-bicyclo (2,2,1) heptane (BCH) uptakes into lymphocytes were measured as prototypes of A- and L-system amino acid transport [2].
Uptake of L-[14C] Leu differed from Gln uptake by its resistance to Arg, Glu, and a relatively high sensitivity to the reference inhibitor of the plasma membrane transport of large neutral amino acids (L-system)--BCH (2-aminobicyclo[2.2.1]heptane-2-carboxylic acid), and a number of natural L-system substrates [3].
The kinetics of decomposition of the following conformationally restricted N-chloro-alpha-amino acids were studied: 1-amino-1-cyclopentanecarboxylic acid (2), 1-amino-1-cyclohexanecarboxylic acid (4), 2-amino-2-norbornanecarboxylic acid (6), and 2-amino-2-benzonorbornanecarboxylic acid (8) [4].
In contrast, the Na+-independent amino acid 2-aminobicyclo(2,2,1)heptane-2-carboxylic acid had no effect on hepatocyte bile acid uptake [5].

Anatomical context of 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid

Respiration of the pancreatic B-cell: effects of glucose and 2-aminonorbornane-2-carboxylic acid [6].

References

Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems. Salter, M., Knowles, R.G., Pogson, C.I. Biochem. J. (1986) [Pubmed]
A multicomponent analysis of amino acid transport systems in human lymphocytes. 1. Kinetic parameters of the A and L systems and pathways of uptake of naturally occurring amino acids in blood lymphocytes. Segel, G.B., Simon, W., Lichtman, M.A. J. Cell. Physiol. (1983) [Pubmed]
Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues. Albrecht, J., Dolińska, M., Hilgier, W., Lipkowski, A.W., Nowacki, J. Neurochem. Int. (2000) [Pubmed]
Kinetics and mechanism of decomposition of N-chloroamino acids. II: conformationally restricted models. Awad, R., Hussain, A., Crooks, P.A. Journal of pharmaceutical sciences. (1990) [Pubmed]
Amino acid inhibition of bile acid uptake by isolated rat hepatocytes: relationship to dissipation of transmembrane Na+ gradient. Blitzer, B.L., Ratoosh, S.L., Donovan, C.B. Am. J. Physiol. (1983) [Pubmed]
Respiration of the pancreatic B-cell: effects of glucose and 2-aminonorbornane-2-carboxylic acid. Hellerström, C., Andersson, A., Welsh, M. Horm. Metab. Res. Suppl. (1980) [Pubmed]

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