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Chemical Compound Review:

HTHQ 4-hexoxy-2,3,6-trimethyl- phenol

Synonyms: ACMC-1C0E0, CCRIS 7478, AG-D-93525, HTHQ-2,3,5, LS-7429, ...

Ito, N. et al., Hirose, M. et al., Liu, W. et al., Hirose, M. et al.

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High impact information on CCRIS 7478

On the other hand, PhIP mammary carcinogenesis was significantly inhibited by coadministration of chlorophyllin or a synthetic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone, in long-term experiments using female F344 rats [1].
Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone [2].
1-O-hexyl-2,3,5-trimethylhydroquinone inhibits IkappaB phosphorylation and degradation-linked inducible nitric oxide synthase expression: beyond antioxidant function [3].

Analytical, diagnostic and therapeutic context of CCRIS 7478

The effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ) and other antioxidants on heterocyclic amine (HCA)-induced rat hepatocarcinogenesis were examined in a medium-term liver bioassay [4].

References

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Ito, N., Hasegawa, R., Imaida, K., Tamano, S., Hagiwara, A., Hirose, M., Shirai, T. Mutat. Res. (1997) [Pubmed]
Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone. Hirose, M., Akagi, K., Hasegawa, R., Satoh, T., Nihro, Y., Miki, T., Sugimura, T., Ito, N. Jpn. J. Cancer Res. (1993) [Pubmed]
1-O-hexyl-2,3,5-trimethylhydroquinone inhibits IkappaB phosphorylation and degradation-linked inducible nitric oxide synthase expression: beyond antioxidant function. Liu, W., Itoigawa, M., Miki, T., Nishikawa, H., Sugiyama, S., Ishikawa, N. J. Pharm. Pharmacol. (2002) [Pubmed]
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments. Hirose, M., Futakuchi, M., Tanaka, H., Orita, S.I., Ito, T., Miki, T., Shirai, T. Eur. J. Cancer Prev. (1998) [Pubmed]

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