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Gene Review

Prdx3  -  peroxiredoxin 3

Mus musculus

Synonyms: AOP-1, AW822249, Antioxidant protein 1, Aop1, D0Tohi1, ...
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Disease relevance of Prdx3


Psychiatry related information on Prdx3


High impact information on Prdx3


Chemical compound and disease context of Prdx3


Biological context of Prdx3


Anatomical context of Prdx3


Associations of Prdx3 with chemical compounds


Physical interactions of Prdx3


Enzymatic interactions of Prdx3


Regulatory relationships of Prdx3

  • In the absence of KatG, antioxidant protection is provided by enhanced expression of the peroxiredoxin AhpC, which is itself reduced by AhpD, a protein with low alkylhydroperoxidase activity of its own [35].
  • Bcl2 is functionally expressed in mitochondria where it can act as an antioxidant that may regulate intracellular reactive oxygen species (ROS) [36].
  • The latter changes may produce oxidant stress, explaining the unexpected finding that leptin induces a battery of genes involved in antioxidant defenses [37].
  • Surprisingly, Nox1-derived H2O2 activated the reporter gene 15-fold with no effect on the redox state of the major thiol antioxidant substances, glutathione and thioredoxin [38].
  • A8 exhibits pleiotropic effects, and the high levels secreted as a result of IL-10 synergy may regulate untoward inflammatory damage by virtue of its an antioxidant capacity [39].

Other interactions of Prdx3


Analytical, diagnostic and therapeutic context of Prdx3


  1. Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. Nonn, L., Berggren, M., Powis, G. Mol. Cancer Res. (2003) [Pubmed]
  2. Ascorbic acid and alpha-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study. Ajith, T.A., Usha, S., Nivitha, V. Clin. Chim. Acta (2007) [Pubmed]
  3. Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells. Yamamoto, T., Matsui, Y., Natori, S., Obinata, M. Gene (1989) [Pubmed]
  4. Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress. Wang, Y., Feinstein, S.I., Manevich, Y., Ho, Y.S., Fisher, A.B. Antioxid. Redox Signal. (2006) [Pubmed]
  5. Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Prediger, R.D., Franco, J.L., Pandolfo, P., Medeiros, R., Duarte, F.S., Di Giunta, G., Figueiredo, C.P., Farina, M., Calixto, J.B., Takahashi, R.N., Dafre, A.L. Behav. Brain Res. (2007) [Pubmed]
  6. Increased "vigilance" of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress. Madhavan, L., Ourednik, V., Ourednik, J. Stem Cells (2006) [Pubmed]
  7. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Veurink, G., Liu, D., Taddei, K., Perry, G., Smith, M.A., Robertson, T.A., Hone, E., Groth, D.M., Atwood, C.S., Martins, R.N. Free Radic. Biol. Med. (2003) [Pubmed]
  8. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons. Ramanathan, L., Gozal, D., Siegel, J.M. J. Neurochem. (2005) [Pubmed]
  9. Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. Ma, X., Idle, J.R., Krausz, K.W., Tan, D.X., Ceraulo, L., Gonzalez, F.J. J. Pineal Res. (2006) [Pubmed]
  10. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Maeda, S., Kamata, H., Luo, J.L., Leffert, H., Karin, M. Cell (2005) [Pubmed]
  11. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Veis, D.J., Sorenson, C.M., Shutter, J.R., Korsmeyer, S.J. Cell (1993) [Pubmed]
  12. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Bruce, A.J., Boling, W., Kindy, M.S., Peschon, J., Kraemer, P.J., Carpenter, M.K., Holtsberg, F.W., Mattson, M.P. Nat. Med. (1996) [Pubmed]
  13. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Irani, K., Xia, Y., Zweier, J.L., Sollott, S.J., Der, C.J., Fearon, E.R., Sundaresan, M., Finkel, T., Goldschmidt-Clermont, P.J. Science (1997) [Pubmed]
  14. Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. Powers, K.A., Szászi, K., Khadaroo, R.G., Tawadros, P.S., Marshall, J.C., Kapus, A., Rotstein, O.D. J. Exp. Med. (2006) [Pubmed]
  15. Effects of low selenium diets on antioxidant status and MPTP toxicity in mice. Sutphin, M.S., Buckman, T.D. Neurochem. Res. (1991) [Pubmed]
  16. Catechin prevents tamoxifen-induced oxidative stress and biochemical perturbations in mice. Parvez, S., Tabassum, H., Rehman, H., Banerjee, B.D., Athar, M., Raisuddin, S. Toxicology (2006) [Pubmed]
  17. Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E. Chester, J.F., Gaissert, H.A., Ross, J.S., Malt, R.A., Weitzman, S.A. J. Natl. Cancer Inst. (1986) [Pubmed]
  18. Evidence for an additional intracellular site of action of probucol in the prevention of oxidative modification of low density lipoprotein. Use of a new water-soluble probucol derivative. Parthasarathy, S. J. Clin. Invest. (1992) [Pubmed]
  19. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., Sadoshima, J. J. Clin. Invest. (2003) [Pubmed]
  20. LTW4 protein on mouse chromosome 1 is a member of a family of antioxidant proteins. Iakoubova, O.A., Pacella, L.A., Her, H., Beier, D.R. Genomics (1997) [Pubmed]
  21. Oxidative stress in leukocytes from young prematurely aging mice is reversed by supplementation with biscuits rich in antioxidants. Alvarado, C., Alvarez, P., Jiménez, L., De la Fuente, M. Dev. Comp. Immunol. (2006) [Pubmed]
  22. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. Chen, F., Lu, Y., Castranova, V., Li, Z., Karin, M. J. Biol. Chem. (2006) [Pubmed]
  23. Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. Ichimiya, S., Davis, J.G., O'Rourke, D.M., Katsumata, M., Greene, M.I. DNA Cell Biol. (1997) [Pubmed]
  24. Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root. Phelan, S.A., Wang, X., Wallbrandt, P., Forsman-Semb, K., Paigen, B. Free Radic. Biol. Med. (2003) [Pubmed]
  25. Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., Yamamoto, M. Mol. Cell. Biol. (2004) [Pubmed]
  26. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. Kang, S.W., Chae, H.Z., Seo, M.S., Kim, K., Baines, I.C., Rhee, S.G. J. Biol. Chem. (1998) [Pubmed]
  27. Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Gosbell, A.D., Stefanovic, N., Scurr, L.L., Pete, J., Kola, I., Favilla, I., de Haan, J.B. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  28. Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia. Wang, Y., Phelan, S.A., Manevich, Y., Feinstein, S.I., Fisher, A.B. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  29. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. Lee, H., Arsura, M., Wu, M., Duyao, M., Buckler, A.J., Sonenshein, G.E. J. Exp. Med. (1995) [Pubmed]
  30. Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. Rachidi, W., Vilette, D., Guiraud, P., Arlotto, M., Riondel, J., Laude, H., Lehmann, S., Favier, A. J. Biol. Chem. (2003) [Pubmed]
  31. Antioxidant imbalance in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Velsor, L.W., van Heeckeren, A., Day, B.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  32. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Wimmer, U., Wang, Y., Georgiev, O., Schaffner, W. Nucleic Acids Res. (2005) [Pubmed]
  33. Glial expression of the 90-kDa heat shock protein (HSP90) and the 94-kDa glucose-regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus. Jeon, G.S., Park, S.W., Kim, D.W., Seo, J.H., Cho, J., Lim, S.Y., Kim, S.D., Cho, S.S. Glia (2004) [Pubmed]
  34. Tissue-specific changes in heme oxygenase activity and level of nonprotein thiols in C57Bl/6 mice after whole-body gamma-irradiation. Han, Y., Platonov, A.G., Akhalaia, M.Y., Song, J.Y., Ahn, J.Y., Yun, Y.S. Bull. Exp. Biol. Med. (2005) [Pubmed]
  35. Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Koshkin, A., Zhou, X.T., Kraus, C.N., Brenner, J.M., Bandyopadhyay, P., Kuntz, I.D., Barry, C.E., Ortiz de Montellano, P.R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  36. Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Deng, X., Gao, F., May, W.S. Blood (2003) [Pubmed]
  37. Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. Liang, C.P., Tall, A.R. J. Biol. Chem. (2001) [Pubmed]
  38. H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1. Go, Y.M., Gipp, J.J., Mulcahy, R.T., Jones, D.P. J. Biol. Chem. (2004) [Pubmed]
  39. Il-10 up-regulates macrophage expression of the S100 protein S100A8. Xu, K., Yen, T., Geczy, C.L. J. Immunol. (2001) [Pubmed]
  40. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. Wang, X., Phelan, S.A., Forsman-Semb, K., Taylor, E.F., Petros, C., Brown, A., Lerner, C.P., Paigen, B. J. Biol. Chem. (2003) [Pubmed]
  41. Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice. Yu, F., Lu, S., Yu, F., Feng, S., McGuire, P.M., Li, R., Wang, R. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  42. Protective activity of Bacopa monniera Linn. on nicotine-induced toxicity in mice. Vijayan, V., Helen, A. Phytotherapy research : PTR (2007) [Pubmed]
  43. Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. Chang, T.S., Cho, C.S., Park, S., Yu, S., Kang, S.W., Rhee, S.G. J. Biol. Chem. (2004) [Pubmed]
  44. Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Kim, B.J., Hood, B.L., Aragon, R.A., Hardwick, J.P., Conrads, T.P., Veenstra, T.D., Song, B.J. Proteomics (2006) [Pubmed]
  45. Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice. Li, L., Ng, T.B., Gao, W., Li, W., Fu, M., Niu, S.M., Zhao, L., Chen, R.R., Liu, F. Life Sci. (2005) [Pubmed]
  46. Antioxidant associated chemoprevention by selenomethionine in murine tumor model. Mukhopadhyay-Sardar, S., Rana, M.P., Chatterjee, M. Mol. Cell. Biochem. (2000) [Pubmed]
  47. The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7 days in mice with acute lung injury. Sciuto, A.M., Cascio, M.B., Moran, T.S., Forster, J.S. Inhalation toxicology. (2003) [Pubmed]
  48. Enhancement of urethan tumorigenesis in mouse lung by butylated hydroxytoluene. Witschi, H., Williamson, D., Lock, S. J. Natl. Cancer Inst. (1977) [Pubmed]
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