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Chemical Compound Review:

SureCN291776 1-methoxy-4-phenyl-benzene

Synonyms: NSC-3793, AG-A-76297, ACMC-209mrk, ANW-33774, HSDB 5502, ...

Fry, J.R., Paterson, P. et al., Smith, R.V. et al., Fry, J.R.

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Disease relevance of HSDB 5502

A total of 45 fungi and actinomycetes were screened for their ability to O-demethylate 4-methoxybiphenyl [1].

High impact information on HSDB 5502

A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microsomes [2].
Influence of substrate concentration on the phase I and phase II metabolism of 4-methoxybiphenyl by rat isolated hepatocytes [3].
Ascorbic acid did not influence the cytochrome P-450-dependent O-demethylation of 4-methoxybiphenyl or the level of cellular lipid peroxidation [4].

Associations of HSDB 5502 with other chemical compounds

1. The metabolism of 4-methoxybiphenyl to 4-hydroxybiphenyl and its sulphate and glucuronic acid conjugates has been studied in rat isolated hepatocytes at various concentrations of 4-methoxybiphenyl [3].

References

Microbial models of mammalian metabolism: O-dealkylation of para-alkoxybiphenyls. Smith, R.V., Milton, S.A., Davis, P.J. Appl. Environ. Microbiol. (1982) [Pubmed]
A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microsomes. Fry, J.R. Biochem. Pharmacol. (1981) [Pubmed]
Influence of substrate concentration on the phase I and phase II metabolism of 4-methoxybiphenyl by rat isolated hepatocytes. Fry, J.R. Xenobiotica (1987) [Pubmed]
The effect of ascorbic acid on the conjugation of 4-hydroxybiphenyl in rat isolated hepatocytes. Paterson, P., Fry, J.R. Xenobiotica (1983) [Pubmed]

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