Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PAPP 4-[2-[4-[3-(trifluoromethyl) phenyl]piperaz...

Synonyms: Lopac-S-009, p-NH2-PE-Tfmpp, S009_SIGMA, CHEMBL1256693, SureCN3976547, ...

Hutson, P.H. et al., Asarch, K.B. et al., Sprouse, J.S. et al., Fuller, R.W. et al.

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High impact information on LY-165163

Serum concentrations of corticosterone and prolactin were increased by doses of LY 165163 that reduced serotonin turnover [1].
Depletion of brain 5-hydroxytryptamine (5-HT) by parachlorophenylalanine (pCPA) prevented the hyperphagic effect over 2 and 4 h after treatment with LY 165163 (1 mg/kg) [2].
LY 165163 increased food intake in non-food-deprived rats over 2, 4 and 24 h after administration [2].
Low microiontophoretic currents of ipsapirone and LY 165163 were also effective in suppressing spontaneous firing; dose-response relationships for the 5-HT1A compounds were indistinguishable from that of 5-HT itself [3].
The ability of m-trifluoromethylphenylpiperazine (TFMPP) and an N-substituted derivative, LY 165163 (p-NH2-PE-TFMPP), to discriminate 5-HT-1 binding sites labelled by [3H]5-HT is compared in rat corpus striatum and rat cortex [4].

References

Central serotonin agonist actions of LY 165163, 1-(m-trifluoromethylphenyl)-4-(p-aminophenylethyl) piperazine, in rats. Fuller, R.W., Snoddy, H.D., Molloy, B.B. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY 165163) at central 5-HT receptors. Hutson, P.H., Donohoe, T.P., Curzon, G. Eur. J. Pharmacol. (1987) [Pubmed]
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Sprouse, J.S., Aghajanian, G.K. Synapse (1987) [Pubmed]
5-HT-1a and 5-HT-1b selectivity of two phenylpiperazine derivatives: evidence for 5-HT-1b heterogeneity. Asarch, K.B., Ransom, R.W., Shih, J.C. Life Sci. (1985) [Pubmed]

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