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Chemical Compound Review

DHFU     5-fluoro-1,3-diazinane-2,4- dione

Synonyms: AGN-PC-00PZG0, AG-L-64219, SureCN2466350, AC1L3TSD, AC1Q6GJT, ...
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Disease relevance of DHFU


High impact information on DHFU


Biological context of DHFU

  • The biologically active isomer of 5-fluoro-5,6-dihydrouracil [(R)-5-fluoro-5,6-dihydrouracil, R-FUH2] was synthesized to study the kinetics of its enzymatic oxidation and hydrolysis by homogeneous dihydropyrimidine dehydrogenase (DPDase) and dihydropyrimidine aminohydrolase (DPHase), respectively [4].


  1. Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. Spector, T., Cao, S., Rustum, Y.M., Harrington, J.A., Porter, D.J. Cancer Res. (1995) [Pubmed]
  2. Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics. Maring, J.G., Piersma, H., van Dalen, A., Groen, H.J., Uges, D.R., De Vries, E.G. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  3. Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans. Sommadossi, J.P., Aubert, C., Cano, J.P., Gouveia, J., Ribaud, P., Mathé, G. Cancer Res. (1983) [Pubmed]
  4. (R)-5-fluoro-5,6-dihydrouracil: kinetics of oxidation by dihydropyrimidine dehydrogenase and hydrolysis by dihydropyrimidine aminohydrolase. Porter, D.J., Harrington, J.A., Almond, M.R., Lowen, G.T., Spector, T. Biochem. Pharmacol. (1994) [Pubmed]
  5. Pharmacokinetics of 5-fluorouracil : impact of the measurement of the 5,6-dihydrofluorouracil. Aubert, C., Cano, J.P., Rigault, J.P., Seitz, J.F., Carcassonne, Y. Bulletin du cancer. (1981) [Pubmed]
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