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Chemical Compound Review

AG-F-61054     (2S)-2-amino-3-[4-(4-hydroxy- 3-iodo...

Synonyms: SureCN1170063, CTK4I9858, AC1L3TW7, 3'-T1, 4732-82-5, ...
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Disease relevance of 3'-monoiodothyronine


High impact information on 3'-monoiodothyronine

  • Cardiac outer ring (5') monodeiodination of 3',5'-diiodothyronine to 3'-monoiodothyronine was also significantly reduced in Tx rats, but it improved significantly only after treatment with the high dose of T3 [4].
  • We conclude that T3 sulfation activity in the rat is 1) most abundant in liver, kidney, and brain tissues of the adult; 2) inhibited more avidly by 3'-monoiodothyronine than other thyronines; 3) very abundant in fetal skin early in gestation; and 4) little affected by the thyroidal status of the animal [5].
  • Serum 3'-monoiodothyronine levels in normal subjects and in patients with thyroid and non-thyroid disease [6].

Analytical, diagnostic and therapeutic context of 3'-monoiodothyronine


  1. Kinetic studies of thyroxine, 3,5,3'-triiodothyronine, 3,3,5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine in patients with liver cirrhosis. Faber, J., Thomsen, H.F., Lumholtz, I.B., Kirkegaard, C., Siersbaek-Nielsen, K., Friis, T. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  2. Metabolic clearance and production rates of 3.3'-diiodothyronine, 3',5'-diiodothyronine and 3'-monoiodothyronine in hyper- and hypothyroidism. Faber, J., Lumholtz, I.B., Kirkegaard, C., Siersbaek-Nielsen, K., Friis, T. Clin. Endocrinol. (Oxf) (1982) [Pubmed]
  3. Metabolism of 3,3'-Diiodothyronine and 3'-monoiodothyronine, and effect of potassium cyanide and dinitrophenol and glucuronidation of thyroxine in cultured rat hepatoma cells. Sorimachi, K., Niwa, A., Yasumura, Y. Endocrinol. Jpn. (1980) [Pubmed]
  4. Thyromimetic effects of 3,5,3'-triiodothyronine sulfate in hypothyroid rats. Santini, F., Hurd, R.E., Lee, B., Chopra, I.J. Endocrinology (1993) [Pubmed]
  5. A study of the 3,5,3'-triiodothyronine sulfation activity in the adult and the fetal rat. Hurd, R.E., Santini, F., Lee, B., Naim, P., Chopra, I.J. Endocrinology (1993) [Pubmed]
  6. Serum 3'-monoiodothyronine levels in normal subjects and in patients with thyroid and non-thyroid disease. Kirkegaard, C., Faber, J., Cohn, D., Kølendorf, K., Thomsen, H.F., Lumholtz, I.B., Siersbaek-Nielsen, K., Friis, T. Acta Endocrinol. (1981) [Pubmed]
  7. A radioimmunoassay for measurement of 3'-monoiodothyronine. Chopra, I.J. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  8. 3'-Monoiodothyronine degradation in rat liver homogenate: enzyme characteristics and documentation of deiodination by high-pressure liquid chromatography. Smallridge, R.C., Whorton, N.E. Metab. Clin. Exp. (1984) [Pubmed]
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