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Chemical Compound Review

FP-Cit     methyl(1R,2S,3S)-8-(3- fluoropropyl)-3-(4...

Synonyms: beta-Cit-FP, AC1L3U61, (123I)FP-Cit, 155797-99-2, (O-Methyl-11C)beta-cit-FP
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Disease relevance of FP-Cit


High impact information on FP-Cit


Analytical, diagnostic and therapeutic context of FP-Cit

  • CONCLUSION: These results indicate that [123I] beta CIT-FP/SPECT can provide quantitative descriptors of presynaptic dopaminergic function comparable to those obtained with [18F]FDOPA/PET [1].
  • UPDRS motor ratings correlated with SOR values obtained by both imaging techniques (r = -0.69 and -0.60, p < 0.04 for [123I] beta CIT-FP and [18F]FDOPA, respectively) [1].
  • Positron emission tomography (PET) studies with [O-methyl-11C] beta-CIT-FP ([11C] beta-CIT-FP) has shown that equilibrium conditions were approached but, however, not reached at the end of measurement [3].
  • The fraction of unchanged [18F] beta-CIT-FP determined by HPLC was 10-15% after 140 min [3].


  1. Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET. Ishikawa, T., Dhawan, V., Kazumata, K., Chaly, T., Mandel, F., Neumeyer, J., Margouleff, C., Babchyck, B., Zanzi, I., Eidelberg, D. J. Nucl. Med. (1996) [Pubmed]
  2. Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines. Okada, T., Fujita, M., Shimada, S., Sato, K., Schloss, P., Watanabe, Y., Itoh, Y., Tohyama, M., Nishimura, T. Nucl. Med. Biol. (1998) [Pubmed]
  3. [18F] beta-CIT-FP is superior to [11C] beta-CIT-FP for quantitation of the dopamine transporter. Lundkvist, C., Halldin, C., Ginovart, N., Swahn, C.G., Farde, L. Nucl. Med. Biol. (1997) [Pubmed]
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