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Chemical Compound Review

Dol-P-glc     [(2S,3R,4S,5S,6R)-3,4,5- trihydroxy-6...

Synonyms: CHEMBL67622, SureCN361623, CHEBI:16218, NCI44138, AR-1C5020, ...
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Disease relevance of Dolichylglucose phosphate


High impact information on Dolichylglucose phosphate

  • Binding was either reduced or absent in the microsomal membranes from two yeast mutants (alg5 and dpg1) that are known to be defective in the synthesis of glucosylphosphodolichol [2].
  • Microsomal membranes from a mutant strain that synthesized glucosylphosphodolichol but lacked the ability to transfer the glucosyl residue to the growing lipid-linked oligosaccharide (alg6) exhibited labeling with 5-azido[beta-32P]UDPGlc comparable to that found in microsomes from the wild-type strain [2].
  • In an effort to identify the polypeptide chain of glucosylphosphodolichol synthase (EC, yeast microsomal membranes were allowed to react with 5-azido[beta-32P]UDPGlc, a photoactive analogue of UDPGlc, which is a substrate for this enzyme [2].
  • The microsomes isolated from a heterozygous diploid strain alg5::dpg1 generated from these two mutants exhibited partial restoration of both the ability to photolabel the 35-kDa protein and the ability to catalyze the synthesis of glucosylphosphodolichol [2].
  • We investigated the acceptor specificity of a thermostable trehalose phosphorylase from Thermoanaerobacter brockii ATCC 35047 (TbTP) was examined using beta-D-glucose-1-phosphate (beta-G1P) as a glucosyl donor and oligosaccharides as the acceptor [3].


  1. Enzymatic synthesis of novel oligosaccharides from L-sorbose, maltose, and sucrose using kojibiose phosphorylase. Chaen, H., Nishimoto, T., Nakada, T., Fukuda, S., Kurimoto, M., Tsujisaka, Y. J. Biosci. Bioeng. (2001) [Pubmed]
  2. Evidence that the synthesis of glucosylphosphodolichol in yeast involves a 35-kDa membrane protein. Palamarczyk, G., Drake, R., Haley, B., Lennarz, W.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Acceptor specificity of trehalose phosphorylase from Thermoanaerobacter brockii: production of novel nonreducing trisaccharide, 6-O-alpha-D-galactopyranosyl trehalose. Maruta, K., Watanabe, H., Nishimoto, T., Kubota, M., Chaen, H., Fukuda, S., Kurimoto, M., Tsujisaka, Y. J. Biosci. Bioeng. (2006) [Pubmed]
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