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Chemical Compound Review:

AC1L3Y37 1-cyclohexyl-1-phenyl-4-(1- piperidyl)butan...

Synonyms: L023948, 113010-69-8, HHD, Hexahydrodifenidol, Hexahydro-diphenidol

Loenders, B. et al., Field, J.L. et al., Freedman, S.B. et al.

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High impact information on Hexahydrodifenidol

Methoctramine and hexahydrodifenidol antagonise two muscarinic responses on the rat superior cervical ganglion with opposite selectivity [1].
Hexahydrodifenidol does not distinguish among M1 receptors in rat cerebral cortex, hippocampus and superior cervical ganglion [2].
The effects of the enantiomers of structurally related chiral M3 antagonists (trihexyphenidyl, p-fluorohexahydrodifenidol, hexahydrodifenidol and p-fluorohexbutinol) were studied at the presynaptic M2 and postsynaptic M3 receptor level in the rabbit trachea [3].

References

Methoctramine and hexahydrodifenidol antagonise two muscarinic responses on the rat superior cervical ganglion with opposite selectivity. Field, J.L., Newberry, N.R. Neurosci. Lett. (1989) [Pubmed]
Hexahydrodifenidol does not distinguish among M1 receptors in rat cerebral cortex, hippocampus and superior cervical ganglion. Freedman, S.B., Field, J.L., Gilbert, M.J., Newberry, N.R. Eur. J. Pharmacol. (1989) [Pubmed]
Effects of enantiomers of M3 antagonists on muscarinic receptors in rabbit trachea. Loenders, B., Rampart, M., Herman, A.G. Archives internationales de pharmacodynamie et de thérapie. (1994) [Pubmed]

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