Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AKOS006273450 2,2-difluorobutane-1,4-diamine

Synonyms: AC1L3Y3P, 113741-09-6, 2,2-Difluoroputrescine, 1,4-Butanediamine, 2,2-difluoro-

Sarhan, S. et al., Seiler, N. et al.

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High impact information on 2,2-Difluoroputrescine

At 24 h after 2,2-difluoroputrescine administration the amount was about 8% of the normal endogenous polyamine pool in the small intestine, but lower in all other tissues [1].
1. Injection of 2,2-difluoroputrescine (DFPut) into the yolk sac of chick embryos causes the formation of 6,6-difluorospermidine (6,6DFSpd) and 6,6-difluorospermine (6,6DFSpm), demonstrating that the difluoroanalogs of putrescine and spermidine are in vivo substrates of spermidine and spermine synthase, respectively [2].

References

Chain-fluorinated polyamines as tumor markers. II. Metabolic aspects in normal tissues. Seiler, N., Sarhan, S., Knödgen, B., Gerhart, F. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine. Sarhan, S., Knodgen, B., Gerhart, F., Seiler, N. Int. J. Biochem. (1987) [Pubmed]

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