Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL77442 N-(3-aminopropyl)-2,2- difluoro-butane-1,4...

Synonyms: AC1L2XTA, 111397-40-1, 6,6-Difluorospermidine

Hull, W.E. et al.

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High impact information on 1,4-Butanediamine, N1-(3-aminopropyl)-2,2-difluoro-

Treatment of laboratory animals bearing transplantable tumours with alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase, followed by 2,2-difluoroputrescine allows the partial replacement of the endogenous polyamines spermidine and spermine by their fluorine-containing analogs 6,6-difluorospermidine and 6,6-difluorospermine [1].

References

Chain-fluorinated polyamines as tumour markers. III. Determination of geminal difluoropolyamines and their precursor 2,2-difluoroputrescine in normal tissues and experimental tumours by in vitro and in vivo 19F NMR spectroscopy. Hull, W.E., Kunz, W., Port, R.E., Seiler, N. NMR in biomedicine. (1988) [Pubmed]

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