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Chemical Compound Review:

Aidurd 1-[(2R,4S,5R)-5- (aminomethyl)-4-hydroxy...

Synonyms: AIDDU, AIDU, CHEMBL1790057, SureCN1045657, CTK8D8428, ...

Otto, M.J. et al., Zucker, M.L. et al., Kan-Mitchell, J. et al., Chen, M.S. et al., Pavan-Langston, D. et al., et al.

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Disease relevance of Aidurd

Specific herpes simplex virus-induced incorporation of 5-iodo-5'-amino-2',5'-dideoxyuridine into deoxyribonucleic acid [1].
Herpes simplex virus type 1 (HSV-1) encoded thymidine kinase converts 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd), a highly specific anti-herpes agent, into the 5'-diphosphate (AIdUDP) derivative in vitro [2].
Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro [3].

High impact information on Aidurd

5-Iodo-5'-amino-2',5'-dideoxyuridine (AldUrd), given as five single i.p. injections on Days 0 to 4 after antigenic challenge with sheep erythrocytes, had no demonstrable effect on serum hemagglutinin titers in doses as high as 2000 mg/kg/day [4].
The phosphorylation of thymidine and iododeoxyuridine by thymidine kinase was stimulated by 5-iodo-5'-amino-2',5'-dideoxyuridine ( AIdUrd ) [5].
Treatment of herpes simplex virus type 1 (HSV-1) infected Vero, BHK, BHKtk- and LMtk- cells with 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd) caused increased synthesis of ICP36 and an increase in HSV-1 thymidine kinase (tk) activity at late times of infection [6].
Exposure of herpes simplex virus type 1 (HSV-1)-infected Vero cells to the nucleoside analogues 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd), 5-iodo-2'-deoxyuridine (IdUrd) or 5'-amino-2',5'-dideoxythymidine (5'-AdThd) resulted in altered expression of HSV-1-induced proteins [7].

Chemical compound and disease context of Aidurd

In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection [8].

References

Specific herpes simplex virus-induced incorporation of 5-iodo-5'-amino-2',5'-dideoxyuridine into deoxyribonucleic acid. Chen, M.S., Ward, D.C., Prusoff, W.H. J. Biol. Chem. (1976) [Pubmed]
Phosphorylation of 5-iodo-5'-amino-2',5',dideoxyuridine by herpes simplex virus type 1 encoded thymidine kinase. Chen, M.S., Prusoff, W.H. J. Biol. Chem. (1979) [Pubmed]
Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro. Iltis, J.P., Lin, T.S., Prusoff, W.H., Rapp, F. Antimicrob. Agents Chemother. (1979) [Pubmed]
Comparative analysis of the immunosuppressive properties of two antiviral, iodinated thymidine analogs, 5-iodo-2'-deoxyuridine and 5-iodo-5'-amino-2',5'-dideoxyuridine. Kan-Mitchell, J., Mitchell, M.S., Lin, T.S., Prusoff, W.H. Cancer Res. (1980) [Pubmed]
Antagonism of feedback inhibition. Stimulation of the phosphorylation of thymidine and 5-iodo-2'-deoxyuridine by 5-iodo-5'-amino-2',5'-dideoxyuridine. Fischer, P.H., Phillips, A.W. Mol. Pharmacol. (1984) [Pubmed]
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues. Zucker, M.L., Mancini, W.R., Otto, M.J., Lee, J.J., Prusoff, W.H. Antiviral Res. (1986) [Pubmed]
Effects of nucleoside analogues on the expression of herpes simplex type 1-induced proteins. Otto, M.J., Lee, J.J., Prusoff, W.H. Antiviral Res. (1982) [Pubmed]
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection. Pavan-Langston, D., Park, N.H., De Clercq, E. Antiviral Res. (1984) [Pubmed]

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