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Chemical Compound Review

2-deoxyglucose     (3R,4S,5R)-3,4,5,6- tetrahydroxyhexanal

Synonyms: D-2dGlc, AG-E-02029, CHEMBL2074932, CHEBI:15866, ANW-21488, ...
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Disease relevance of Deoxyglucose


Psychiatry related information on Deoxyglucose


High impact information on Deoxyglucose

  • In vivo, these mutations not only result in a substantial decrease in insulin-stimulated IR autophosphorylation but also in a parallel decrease in the insulin-activated uptake of 2-deoxyglucose [11].
  • Treatment of density-inhibited cultures of normal chick embryo fibroblasts with trypsin, plasmin, neuraminidase, or hyaluronidase stimulated their rate of 2-deoxyglucose uptake to a level only marginally higher than that seen in normal exponentially growing cultures, and only 35-45% of that seen in transformed cultures [12].
  • All of these proteases, when added to the culture medium at concentrations of 0.08-2.2 mug/ml, stimulated deoxyglucose uptake and induced cell division [13].
  • A decrease in the expression of endogenous Myo1c mediated by small interfering RNAs inhibits insulin-stimulated uptake of 2-deoxyglucose [14].
  • Development of orientation columns in cat striate cortex revealed by 2-deoxyglucose autoradiography [15].

Chemical compound and disease context of Deoxyglucose


Biological context of Deoxyglucose


Anatomical context of Deoxyglucose


Associations of Deoxyglucose with other chemical compounds


Gene context of Deoxyglucose


Analytical, diagnostic and therapeutic context of Deoxyglucose


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  2. 2-Deoxy-D-glucose maps movement-specific nervous activity in the second visual ganglion of Drosophila. Buchner, E., Buchner, S., Hengstenberg, R. Science (1979) [Pubmed]
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  5. Successful treatment of human genital herpes infections with 2-deoxy-D-glucose. Blough, H.A., Giuntoli, R.L. JAMA (1979) [Pubmed]
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  11. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Ellis, L., Clauser, E., Morgan, D.O., Edery, M., Roth, R.A., Rutter, W.J. Cell (1986) [Pubmed]
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  16. Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats. Zhang, L., Xing, L.P., Demers, L., Washington, J., Kauffman, G.L. Gastroenterology (1989) [Pubmed]
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  21. Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats. Stricker, E.M., Zimmerman, M.B., Friedman, M.I., Zigmond, M.J. Nature (1977) [Pubmed]
  22. Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy. Deuel, R.K., Yue, G.M., Sherman, W.R., Schickner, D.J., Ackerman, J.J. Science (1985) [Pubmed]
  23. Fc receptor modulation in mononuclear phagocytes maintained on immobilized immune complexes occurs by diffusion of the receptor molecule. Michl, J., Pieczonka, M.M., Unkeless, J.C., Bell, G.I., Silverstein, S.C. J. Exp. Med. (1983) [Pubmed]
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  27. Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker. Schwartz, W.J., Gainer, H. Science (1977) [Pubmed]
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  31. Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate. Segal, J., Ingbar, S.H. J. Clin. Invest. (1981) [Pubmed]
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  34. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Wijesekara, N., Konrad, D., Eweida, M., Jefferies, C., Liadis, N., Giacca, A., Crackower, M., Suzuki, A., Mak, T.W., Kahn, C.R., Klip, A., Woo, M. Mol. Cell. Biol. (2005) [Pubmed]
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