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Chemical Compound Review

2-deoxyglucose     (3R,4S,5R)-3,4,5,6- tetrahydroxyhexanal

Synonyms: D-2dGlc, AG-E-02029, CHEMBL2074932, CHEBI:15866, ANW-21488, ...
 
 
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Disease relevance of Deoxyglucose

 

Psychiatry related information on Deoxyglucose

 

High impact information on Deoxyglucose

  • In vivo, these mutations not only result in a substantial decrease in insulin-stimulated IR autophosphorylation but also in a parallel decrease in the insulin-activated uptake of 2-deoxyglucose [11].
  • Treatment of density-inhibited cultures of normal chick embryo fibroblasts with trypsin, plasmin, neuraminidase, or hyaluronidase stimulated their rate of 2-deoxyglucose uptake to a level only marginally higher than that seen in normal exponentially growing cultures, and only 35-45% of that seen in transformed cultures [12].
  • All of these proteases, when added to the culture medium at concentrations of 0.08-2.2 mug/ml, stimulated deoxyglucose uptake and induced cell division [13].
  • A decrease in the expression of endogenous Myo1c mediated by small interfering RNAs inhibits insulin-stimulated uptake of 2-deoxyglucose [14].
  • Development of orientation columns in cat striate cortex revealed by 2-deoxyglucose autoradiography [15].
 

Chemical compound and disease context of Deoxyglucose

 

Biological context of Deoxyglucose

 

Anatomical context of Deoxyglucose

 

Associations of Deoxyglucose with other chemical compounds

 

Gene context of Deoxyglucose

 

Analytical, diagnostic and therapeutic context of Deoxyglucose

References

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