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Chemical Compound Review:

AG-A-29102 1-oxido-2-pyridin-2-yl-indol- 3-one

Synonyms: AC1Q1WBT, CTK5I4433, ZINC02573143, AR-1C7000, AKOS004904829, ...

Ren, L.M. et al., Chapal, J. et al., Menton, K. et al., Gao, Z.G. et al., King, B.F. et al.

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High impact information on 1-oxido-2-pyridin-2-yl-indol-3-one

2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding [1].
Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2,2'-pyridylisatogen tosylate [2].
Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor [3].
In contrast, 2,2'-pyridylisatogen tosylate did not modify the first phase of insulin response to 8.3 or 12.5 mM glucose in pancreas previously perfused with 4.2 mM glucose [4].

Analytical, diagnostic and therapeutic context of 1-oxido-2-pyridin-2-yl-indol-3-one

3. 2,2'-Pyridylisatogen tosylate (PIT, 0.3-3 microM) significantly potentiated the vasoconstrictions to electrical stimulation at 2-32 Hz in a concentration-dependent manner [2].
Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds [5].

References

2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Gao, Z.G., Mamedova, L., Tchilibon, S., Gross, A.S., Jacobson, K.A. Biochem. Pharmacol. (2004) [Pubmed]
Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2,2'-pyridylisatogen tosylate. Ren, L.M., Burnstock, G. Br. J. Pharmacol. (1997) [Pubmed]
Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. King, B.F., Dacquet, C., Ziganshin, A.U., Weetman, D.F., Burnstock, G., Vanhoutte, P.M., Spedding, M. Br. J. Pharmacol. (1996) [Pubmed]
Prior glucose deprivation increases the first phase of glucose-induced insulin response: possible involvement of endogenous ATP and (or) ADP. Chapal, J., Bertrand, G., Hillaire-Buys, D., Gross, R., Loubatières-Mariani, M.M. Can. J. Physiol. Pharmacol. (1993) [Pubmed]
Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds. Menton, K., Spedding, M., Gressens, P., Villa, P., Williamson, T., Markham, A. Eur. J. Pharmacol. (2002) [Pubmed]

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