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Chemical Compound Review

Dns-C6-cho     2-[6-[(5- dimethylaminonaphthalen-1...

Synonyms: AC1L3YYD, AC1Q1RHZ, AR-1D7503, A833887, Dansyl-C6-choline
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High impact information on 2-[6-[(5-dimethylaminonaphthalen-1-yl)sulfonylamino]hexanoyloxy]ethyl-trimethyl-azanium

  • The compound with the most interesting properties (high affinity and selectivity for the acetylcholine binding site, as well as agonist activity and high photolabeling yield) is AC5, a structural analogue of the fluorescent agonist dansyl-C6-choline, which has been previously used to characterize the different states of the nicotinic receptor [1].
  • To include any effects on the local potentials by the bound acceptor fluorophore crystal violet, its binding site was first localized within the pore by fluorescence energy transfer measurements from dansyl-C6-choline bound to the agonist sites and also by simulations of binding using Autodock [2].
  • Examination of the binding kinetics of the fluorescent acetylcholine analog dansyl-C6-choline at ionic strengths from 12.5 to 400 mM revealed a twofold decrease in association rate [3].
  • The KD for the low-affinity binding site was determined to be 1.1 microM from the increase in the amplitude of the fast decay with Dns-C6-Cho concentration with preincubation times that were sufficiently brief to minimize affinity state conversion [4].
  • Agonist-induced desensitization was characterized from the time-dependent increase in fluorescence intensity that results from the binding of the fluorescent acetylcholine analog, Dns-C6-Cho, to the nAcChoR [5].

Biological context of 2-[6-[(5-dimethylaminonaphthalen-1-yl)sulfonylamino]hexanoyloxy]ethyl-trimethyl-azanium

  • Stopped-flow fluorescence kinetics showed that dissociation of dansyl-C6-choline from the AChR in the desensitized conformation occurs 5-10-fold faster from the alpha gamma site than from the alpha delta site [6].

Anatomical context of 2-[6-[(5-dimethylaminonaphthalen-1-yl)sulfonylamino]hexanoyloxy]ethyl-trimethyl-azanium


  1. Photoactivatable agonist of the nicotinic acetylcholine receptor: potential probe to characterize the structural transitions of the acetylcholine binding site in different states of the receptor. Chatrenet, B., Kotzba-Hibert, F., Mulle, C., Changeux, J.P., Goeldner, M.P., Hirth, C. Mol. Pharmacol. (1992) [Pubmed]
  2. Computed pore potentials of the nicotinic acetylcholine receptor. Meltzer, R.H., Vila-Carriles, W., Ebalunode, J.O., Briggs, J.M., Pedersen, S.E. Biophys. J. (2006) [Pubmed]
  3. Electrostatic steering at acetylcholine binding sites. Meltzer, R.H., Thompson, E., Soman, K.V., Song, X.Z., Ebalunode, J.O., Wensel, T.G., Briggs, J.M., Pedersen, S.E. Biophys. J. (2006) [Pubmed]
  4. Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy. Raines, D.E., Krishnan, N.S. Biochemistry (1998) [Pubmed]
  5. General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Raines, D.E., Rankin, S.E., Miller, K.W. Anesthesiology (1995) [Pubmed]
  6. Site-selective agonist binding to the nicotinic acetylcholine receptor from Torpedo californica. Song, X.Z., Andreeva, I.E., Pedersen, S.E. Biochemistry (2003) [Pubmed]
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