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Chemical Compound Review:

Nbd-AP-mpf 2-[5-(fluoro-methyl- phosphoryl)oxypentyl]...

Synonyms: AR-1L0796, AC1L3Z41, AC1Q4OW4, A844115

Edery, H. et al., Zheng, S. et al.

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Disease relevance of Nbd-AP-mpf

Reversal of the hypotension by HI-6 occurred irrespective of whether the organophosphorus agent was NBD-AP-MPF, which forms conjugates with acetylcholinesterase that undergo no aging, or soman, which forms conjugates that undergo extensive aging rendering the enzyme refractory to oxime reactivation [1].

Psychiatry related information on Nbd-AP-mpf

Both echothiophate and NBD-AP-MPF infusions produced dose-dependent increases in locomotor activity that were accompanied by increased holepoking and rearing [2].

High impact information on Nbd-AP-mpf

By virtue of the fluorescence distribution of NBD-AP-MPF the chemosensitive sites were estimated to reside no deeper than 50 microns into the medulla oblongata, providing a direct indication for localization of the chemosensitive cells on the superficial surface [1].
Topical application of soman (1-5 micrograms) or NBD-AP-MPF (5-120 micrograms) elicited a profound (80-90 mm Hg), long-lasting (0.5-3 h), dose-dependent vasodepression with only minor changes in heart rate and respiration [1].

References

Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents. Edery, H., Geyer, M.A., Taylor, P., Berman, H.A. Journal of autonomic pharmacology. (1986) [Pubmed]
Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation. Zheng, S., Berman, H.A., Geyer, M.A. Behav. Brain Res. (1983) [Pubmed]

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