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Chemical Compound Review

Ecothiopate     2- diethoxyphosphorylsulfanylethy l...

Synonyms: Phospholine, Ecothiopatum, Echothiophate, CHEBI:4753, CHEMBL1201341, ...
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Disease relevance of C06975


Psychiatry related information on C06975


High impact information on C06975

  • RBCs at a hematocrit of 10% (treated with echothiophate to block erythrocyte cholinesterase) did not prevent relaxation but reversed the platelet inhibition [9].
  • Intact leech ganglia were stained for AChE activity with and without echothiophate pretreatment [10].
  • The pattern of activity in the gradient was the same when intact ganglia were pretreated with echothiophate, although the total activity was reduced by 98% [10].
  • Elec-410 appears to bind to one side of the active gorge, whereas Elec-403 covers its opening, explaining why the AChE-Elec-410 complex reacts faster than the AChE-Elec-403 or AChE-fasciculin complexes with two active site inhibitors, m-(N,N, N-trimethyltammonio)trifluoro-acetophenone and echothiophate [11].
  • Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging [12].

Chemical compound and disease context of C06975


Biological context of C06975


Anatomical context of C06975


Associations of C06975 with other chemical compounds


Gene context of C06975


Analytical, diagnostic and therapeutic context of C06975


  1. Hazards of succinylcholine administration during electrotherapy. Packman, P.M., Meyer, D.A., Verdun, R.M. Arch. Gen. Psychiatry (1978) [Pubmed]
  2. Synthesis and properties of 2-S-(N,N-dialkylamino)ethyl)thio-1,3,2-dioxaphosphorinane 2-oxide and of the corresponding quaternary derivatives as potential nontoxic antiglaucoma agents. Amitai, G., Ashani, Y., Grunfeld, Y., Kalir, A., Cohen, S. J. Med. Chem. (1976) [Pubmed]
  3. The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion. Streichert, L.C., Sargent, P.B. J. Physiol. (Lond.) (1992) [Pubmed]
  4. Substance P in the human iris: possible involvement in echothiophate-induced miosis in cluster headache. Fanciullacci, M., Pietrini, U., Geppetti, P., Nicolodi, M., Curradi, C., Sicuteri, F. Cephalalgia : an international journal of headache. (1988) [Pubmed]
  5. Induction of subcapsular cataracts in cynomolgus monkeys by echothiophate. Kaufman, P.L., Axelsson, U., Bárány, E.H. Arch. Ophthalmol. (1977) [Pubmed]
  6. Prevention of precipitated withdrawal symptoms by activating central cholinergic systems during a dependence-producing schedule of morphine in rats. Buccafusco, J.J., Zhang, L.C., Shuster, L.C., Jonnala, R.R., Gattu, M. Brain Res. (2000) [Pubmed]
  7. Electroconvulsive therapy and the chronic use of pseudocholinesterase-inhibitor (echothiophate iodide) eye drops for glaucoma. A case report. Messer, G.J., Stoudemire, A., Knos, G., Johnson, G.C. General hospital psychiatry. (1992) [Pubmed]
  8. Serine hydrolase targets of organophosphorus toxicants. Casida, J.E., Quistad, G.B. Chem. Biol. Interact. (2005) [Pubmed]
  9. Inhibition of intravascular platelet aggregation by endothelium-derived relaxing factor: reversal by red blood cells. Houston, D.S., Robinson, P., Gerrard, J.M. Blood (1990) [Pubmed]
  10. Characterization of acetylcholinesterase in individual neurons in the leech central nervous system. Wallace, B.G., Gillon, J.W. J. Neurosci. (1982) [Pubmed]
  11. The binding sites of inhibitory monoclonal antibodies on acetylcholinesterase. Identification of a novel regulatory site at the putative "back door". Simon, S., Le Goff, A., Frobert, Y., Grassi, J., Massoulié, J. J. Biol. Chem. (1999) [Pubmed]
  12. Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging. Nachon, F., Asojo, O.A., Borgstahl, G.E., Masson, P., Lockridge, O. Biochemistry (2005) [Pubmed]
  13. Atropine inhibition of echothiophate cataractogenesis in monkeys. Kaufman, P.L., Axelsson, U., Bárány, E.H. Arch. Ophthalmol. (1977) [Pubmed]
  14. Intraocular pressure response to the replacement of pilocarpine or carbachol with echothiophate. Reichert, R.W., Shields, M.B. Graefes Arch. Clin. Exp. Ophthalmol. (1991) [Pubmed]
  15. Clonidine protection from soman and echothiophate toxicity in mice. Aronstam, R.S., Smith, M.D., Buccafusco, J.J. Life Sci. (1986) [Pubmed]
  16. Cycloplegic refraction after echothiophate iodide. Raab, E.L. Journal of pediatric ophthalmology and strabismus. (1983) [Pubmed]
  17. A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase. Lockridge, O., Blong, R.M., Masson, P., Froment, M.T., Millard, C.B., Broomfield, C.A. Biochemistry (1997) [Pubmed]
  18. The origin of the anticholinesterase-induced repetitive activity of the phrenic nerve-diaphragm preparation of the rat in vitro. Ferry, C.B. Br. J. Pharmacol. (1988) [Pubmed]
  19. Acetylcholinesterase promotes regeneration of neurites in cultured adult neurons of Aplysia. Srivatsan, M., Peretz, B. Neuroscience (1997) [Pubmed]
  20. The origin of the effects of an anticholinesterase on the latencies of action potentials in mouse skeletal muscles. Kelly, S.S., Ferry, C.B. Br. J. Pharmacol. (1994) [Pubmed]
  21. Echothiophate-induced structural alterations in the anterior chamber angle of the cynomolgus monkey. Lütjen-Drecoll, E., Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  22. H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys. Gabelt, B.T., Hennes, E.A., Seeman, J.L., Tian, B., Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  23. Compartmentation and regulation of acetylcholine synthesis at the synapse. Willoughby, J., Harvey, S.A., Clark, J.B. Biochem. J. (1986) [Pubmed]
  24. Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle. Henderson, E.G., Post-Munson, D.J., Reynolds, L.S., Epstein, P.M. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  25. Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation. Zheng, S., Berman, H.A., Geyer, M.A. Behav. Brain Res. (1983) [Pubmed]
  26. Chimeric human cholinesterase. Identification of interaction sites responsible for recognition of acetyl- or butyrylcholinesterase-specific ligands. Loewenstein, Y., Gnatt, A., Neville, L.F., Soreq, H. J. Mol. Biol. (1993) [Pubmed]
  27. Early lens changes in Macaca fascicularis monkeys under topical treatment with echothiophate or carbachol studied by slit-image photography. Albrecht, M., Bárány, E. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  28. Cholinergic drugs alter ciliary muscle response and receptor content. Erickson-Lamy, K.A., Polansky, J.R., Kaufman, P.L., Zlock, D.M. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  29. Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Li, B., Sedlacek, M., Manoharan, I., Boopathy, R., Duysen, E.G., Masson, P., Lockridge, O. Biochem. Pharmacol. (2005) [Pubmed]
  30. DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase. Boeck, A.T., Schopfer, L.M., Lockridge, O. Biochem. Pharmacol. (2002) [Pubmed]
  31. Butyrylcholinesterase and acetylcholinesterase activity and quantal transmitter release at normal and acetylcholinesterase knockout mouse neuromuscular junctions. Minic, J., Chatonnet, A., Krejci, E., Molgó, J. Br. J. Pharmacol. (2003) [Pubmed]
  32. Turnover of acetylcholinesterase in innervated and denervated rat diaphragm. Newman, J.R., Virgin, J.B., Younkin, L.H., Younkin, S.G. J. Physiol. (Lond.) (1984) [Pubmed]
  33. Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter. Rogers, M., Sargent, P.B. Eur. J. Neurosci. (2003) [Pubmed]
  34. A comparison of the electrophysiological effects of two organophosphates, mipafox and ecothiopate, on mouse limb muscles. de Blaquière, G.E., Williams, F.M., Blain, P.G., Kelly, S.S. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  35. Protection against the effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles. Kelly, S.S., Ferry, C.B., Bamforth, J.P., Das, S.K. Br. J. Pharmacol. (1992) [Pubmed]
  36. Differential effects of denervation on acetylcholinesterase activity in parasympathetic and sympathetic ganglia of the frog, Rana pipiens. Streichert, L.C., Sargent, P.B. J. Neurobiol. (1990) [Pubmed]
  37. Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats. Abram, S.E., Winne, R.P. Anesth. Analg. (1995) [Pubmed]
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