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Chemical Compound Review

HTFMT     6-[2-(3H-imidazol-4- yl)ethylamino]-N-[4...

Synonyms: CHEMBL67601, AC1L3Z71, L024081, 103827-16-3, NCGC00024706-02, ...
 
 
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Disease relevance of Histamine trifluoromethyl-toluidide

 

High impact information on Histamine trifluoromethyl-toluidide

 

Anatomical context of Histamine trifluoromethyl-toluidide

 

Associations of Histamine trifluoromethyl-toluidide with other chemical compounds

  • The regulatory effects of adenosine 3',5'-cyclic monophosphate (cAMP) on Ca2+ flux and phosphatidylinositol (PI) turnover in human lymphocytes were studied. cAMP did not affect the intracellular accumulation of Ca2+ induced by phytohemagglutinin (PHA) and histamine-trifluoromethyl toluidide derivative (HTMT) in peripheral blood lymphocytes (PBL) [6].

References

  1. Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism. Hagelüken, A., Burde, R., Nürnberg, B., Harhammer, R., Buschauer, A., Seifert, R. Naunyn Schmiedebergs Arch. Pharmacol. (1995) [Pubmed]
  2. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. Whyment, A.D., Blanks, A.M., Lee, K., Renaud, L.P., Spanswick, D. J. Neurophysiol. (2006) [Pubmed]
  3. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Qiu, R., Melmon, K.L., Khan, M.M. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  4. A histamine derivative increases intracellular calcium mobilization and oxidative metabolism in HL-60 cells. Qiu, R., Melmon, K.L., Khan, M.M. Immunopharmacology (1993) [Pubmed]
  5. G-protein-coupled receptors in HL-60 human leukemia cells. Klinker, J.F., Wenzel-Seifert, K., Seifert, R. Gen. Pharmacol. (1996) [Pubmed]
  6. Cyclic AMP is not a direct regulator of calcium flux and hydrolysis of phosphoinositides in human lymphocytes. Qiu, R., Melmon, K.L., Khan, M.M. Immunopharmacology (1993) [Pubmed]
 
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