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Chemical Compound Review:

BVPAM tert-butyl N-[(2S)-1-[(2S)-2-[[(2S)-5...

Synonyms: AR-1K0260, FT-0640995, AC1L2O5N, AC1Q5XN1, Boc-val-pro-arg-mca, ...

Kennedy, A.R., Suzuki, Y. et al., Komori, Y. et al., Wan, X.S. et al., Mori, S. et al., et al.

Wan, Meyskens, Armstrong, Taylor, Kennedy,

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Disease relevance of Boc-val-pro-arg-mca

In the first experiment using an infected dorsal pouch of rats, exudate containing proteinases from pouches contaminated with Staphylococcus aureus or Pseudomonas aeruginosa showed significantly higher hydrolytic activity toward Boc-Val-Pro-Arg-MCA than that from noninfected wounds [1].

High impact information on Boc-val-pro-arg-mca

The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies [2].
Among the activities tested, only Boc-Val-Pro-Arg-MCA-hydrolyzing enzyme of the muscle microsomes showed an about 6-fold higher level of activity in mdx mouse [3].
The purified enzyme has a mol. wt of 57,000 and catalysed the hydrolysis of arginine esters and thrombin substrates Boc-Val-Pro-Arg-MCA and Boc-Asp(OBz)-Pro-Arg-MCA [4].
A protease preparation obtained from HeLa cells by sonication and ultrafiltration through a molecular sieve membrane strongly hydrolyzed the fluorescent peptides Boc-Val-Pro-Arg-MCA and Bz-Arg-MCA [5].
Effects of protease inhibitors on the following phenomena are thought to be related to their anticarcinogenic activity: 1) ability to effect the expression of certain oncogenes, and 2) ability to return carcinogen-increased levels of certain proteolytic activities (e.g., Boc-val-pro-arg-MCA hydrolyzing activity) to normal levels [6].

Anatomical context of Boc-val-pro-arg-mca

Prothrombin activity was evaluated in primary cultured rat hepatocytes using synthetic fluorogenic peptide substrates (Boc-Val-Pro-Arg-MCA) [7].

References

A novel wound dressing with an antibiotic delivery system stimulated by microbial infection. Suzuki, Y., Tanihara, M., Nishimura, Y., Suzuki, K., Kakimaru, Y., Shimizu, Y. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1997) [Pubmed]
Relationship between protease activity and neu oncogene expression in patients with oral leukoplakia treated with the Bowman Birk Inhibitor. Wan, X.S., Meyskens, F.L., Armstrong, W.B., Taylor, T.H., Kennedy, A.R. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
Preclinical increase in activity of muscle microsomal trypsin-like protease in murine muscular dystrophy, C57BL/10-mdx. Sawada, H., Tsuji, S., Kusumoto, S., Doi, Y., Matsushita, H. FEBS Lett. (1986) [Pubmed]
Effect of bilineobin, a thrombin-like proteinase from the venom of common cantil (Agkistrodon bilineatus). Komori, Y., Nikai, T., Ohara, A., Yagihashi, S., Sugihara, H. Toxicon (1993) [Pubmed]
Inhibition of growth of HeLa cells by new synthetic protease inhibitors. Mori, S., Kozaki, Y., Kato, M., Tendo, A., Kikawa, Y., Sekine, H., Muramatu, M. J. Biochem. (1984) [Pubmed]
Potential mechanisms of antitumorigenesis by protease inhibitors. Kennedy, A.R. Basic Life Sci. (1993) [Pubmed]
Effect of vitamin K on carbon tetrachloride-induced cellular damage in primary cultured rat hepatocytes. Itoh, Y., Terano, A. Gastroenterol. Jpn. (1990) [Pubmed]

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