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Chemical Compound Review

CHEMBL68649     N-[(2S,6R,9aR)-6-methyl- 2,3,4,6,7,8,9,9a...

Synonyms: BMY-27709, AC1L2RSV, AC1Q3LRY, DNC000334, AR-1G0710, ...
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Disease relevance of Brl 20627


High impact information on Brl 20627

  • This compound (BMY-27709) has an IC50 of 3-8 microM for A/WSN/33 virus growth in a multicycle replication assay and is active against all H1 and H2 subtype viruses tested [2].
  • That this single mutation was responsible for the acquisition of resistance to BMY-27709 was proven through reverse genetics, as transfectant virus containing only this change was shown to be resistant to BMY-27709, while the control virus without this mutation remained sensitive [2].

Analytical, diagnostic and therapeutic context of Brl 20627

  • Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system [3].


  1. Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus. Luo, G., Torri, A., Harte, W.E., Danetz, S., Cianci, C., Tiley, L., Day, S., Mullaney, D., Yu, K.L., Ouellet, C., Dextraze, P., Meanwell, N., Colonno, R., Krystal, M. J. Virol. (1997) [Pubmed]
  2. Characterization of a hemagglutinin-specific inhibitor of influenza A virus. Luo, G., Colonno, R., Krystal, M. Virology (1996) [Pubmed]
  3. Salicylamide inhibitors of influenza virus fusion. Combrink, K.D., Gulgeze, H.B., Yu, K.L., Pearce, B.C., Trehan, A.K., Wei, J., Deshpande, M., Krystal, M., Torri, A., Luo, G., Cianci, C., Danetz, S., Tiley, L., Meanwell, N.A. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
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