Disease relevance of Nitrofurfural

• Furthermore HMF and photoactivated nitrofurfural can induce repairable DNA damage in Escherichia coli bacteria [1].

High impact information on Nitrofurfural

• Metabolic and photochemical hydroxylation of 5-nitro-2-furancarboxaldehyde derivatives [2].
• The physico-chemical properties of some 5-nitro-2-furaldehyde semicarbazones (nitrofurazones) and thiophene analogues were compared with their in vitro and in vivo trypanocidal activity against Trypanosoma cruzi (Tulahuen strain) [3].
• Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. structure-activity relationships [4].
• These compounds were tested in vitro as potential antitrypanosomal agents, and some of them, together with the parent compounds, 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives, were also evaluated in vivo using infected mice [4].
• Irreversible photobinding of nitrofurantoin and of nitrofurfural to plasma proteins in vitro [5].

Chemical compound and disease context of Nitrofurfural

• Analysis of partially purified crude extract of Escherichia coli K12 by chromatography and gel electrophoresis has resulted in the separation of three distinct activities which catalyse the reduction of nitrofurazone (semicarbazone of 5-nitro-2-furaldehyde) in the presence of oxygen (type I nitroreductases) [6].

Biological context of Nitrofurfural

• Cytotoxicity and induction of repairable DNA damage by photoactivated 5-nitrofurfural [1].
• The present studies report that 5-nitro-2-furaldehyde diacetate is also a potent inhibitor of primary ADP-induced platelet aggregation [7].
• The major product of this reaction mixture, 4- nitrofurfural , exhibited no mutagenicity toward tester strains TA98 and TA100 with or without metabolic activation [8].

Gene context of Nitrofurfural

• 5-Nitro-2-furaldehyde (NFA) forms in alkaline solutions an anion of nitronic acid of (5-nitro-furan-2-yl)-methanediol [9].

References