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Chemical Compound Review:

CCRIS 1182 N-amino-N-methyl-methanamide

Synonyms: AG-H-02326, HSDB 3510, LS-7137, NSC-122452, CTK3I9476, ...

Bergman, K. et al., Toth, B. et al., Toth, B. et al., Toth, B. et al., Toth, B. et al., et al.

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Disease relevance of N-amino-N-methyl-methanamide

Separate administrations of 0.0005 to 0.00025% N-methyl-N-formylhydrazine in drinking water to 6-week-old randomly bred Swiss mice for the remainder of their lifetime induced lung neoplasms [1].
N-Methyl-N-formylhydrazine (MFH), an ingredient of the edible false morel mushroom, was administered to Swiss mice as 40 weekly subcutaneous injections at 20 micrograms/g body weight for females and 10 micrograms/g body weight for males [2].

High impact information on N-amino-N-methyl-methanamide

Continuous administration of 0.0078% N-methyl-N-formylhydrazine (MFH) in drinking water to 6-week-old outbred Swiss mice for life produced tumors of the liver, lung, gallbladder, and bile duct [3].
The hydrolysis of acetaldehyde-N-methyl-N-formylhydrazone (gyromitrin, the main toxic component of false morel) results in the formation of the methylating agents N-methyl-N-formylhydrazine (MFH) and N-methylhydrazine (MMH) (by further hydrolysis of MFH) [4].
An involvement of the diamine oxidase inhibitory property of N-methyl-N-formylhydrazine in toxic and mutagenic effects of the substance is considered [5].
N-Methyl-N-formylhydrazine was administered in drinking water as a 0.0039% solution to randomly bred Swiss albino mice for life starting from 6 weeks of age [6].

References

Tumorigenicity of minute dose levels of N-methyl-N-formylhydrazine of Gyromitra esculenta. Toth, B., Patil, K. Mycopathologia (1982) [Pubmed]
Tumorigenic action of repeated subcutaneous administration of N-methyl-N-formylhydrazine in mice. Toth, B., Patil, K. Neoplasma (1983) [Pubmed]
Tumors induced in mice by N-methyl-N-formylhydrazine of the false morel Gyromitra esculenta. Toth, B., Nagel, D. J. Natl. Cancer Inst. (1978) [Pubmed]
Methylation of rat and mouse DNA by the mushroom poison gyromitrin and its metabolite monomethylhydrazine. Bergman, K., Hellenäs, K.E. Cancer Lett. (1992) [Pubmed]
N-methyl-N-formylhydrazine: a toxic and mutagenic inhibitor of the intestinal diamine oxidase. Biegański, T., Braun, R., Kusche, J. Agents Actions (1984) [Pubmed]
False morel mushroom Gyromitra esculenta toxin: N-methyl-N-formylhdrazine carcinogenesis in mice. Toth, B., Patil, K., Erickson, J., Kupper, R. Mycopathologia (1979) [Pubmed]

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