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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Gallbladder


Psychiatry related information on Gallbladder


High impact information on Gallbladder

  • On the basis of an intention-to-treat analysis of all 600 patients, 21 percent receiving ursodiol and 9 percent receiving placebo (P less than 0.0001) had gallbladders that were free of stones after six months [9].
  • The patients with gallbladder stones received adjuvant treatment with a combination of ursodeoxycholic acid and chenodeoxycholic acid [10].
  • The concentration of TGF-beta1 in the plasma of mice with gallbladder tumors was 300% higher than that in the plasma of mice without tumors or with subcutaneous tumors [11].
  • We implanted a gel impregnated with basic fibroblast growth factor or Mz-ChA-2 tumor in the cranial windows of mice without tumors or mice with subcutaneous or gallbladder tumors to study angiogenesis and tumor growth at a secondary site [11].
  • We found that a wide variety of human gallbladder tumors express TGF-beta1 irrespective of histologic type [11].

Chemical compound and disease context of Gallbladder


Biological context of Gallbladder


Anatomical context of Gallbladder


Associations of Gallbladder with chemical compounds


Gene context of Gallbladder


Analytical, diagnostic and therapeutic context of Gallbladder


  1. Dissolution of cholesterol gallbladder stones by methyl tert-butyl ether administered by percutaneous transhepatic catheter. Thistle, J.L., May, G.R., Bender, C.E., Williams, H.J., LeRoy, A.J., Nelson, P.E., Peine, C.J., Petersen, B.T., McCullough, J.E. N. Engl. J. Med. (1989) [Pubmed]
  2. Abnormalities of serum cholecystokinin and gallbladder emptying in celiac disease. Low-Beer, T.S., Harvey, R.F., Davies, E.R., Read, A.F. N. Engl. J. Med. (1975) [Pubmed]
  3. Elevated carcinoembryonic antigen levels and biliary tract obstruction. Lurie, B.B., Loewenstein, M.S., Zamcheck, N. JAMA (1975) [Pubmed]
  4. The disease burden associated with overweight and obesity. Must, A., Spadano, J., Coakley, E.H., Field, A.E., Colditz, G., Dietz, W.H. JAMA (1999) [Pubmed]
  5. Effects of phenobarbital and secondary bile acids on liver, gallbladder, and pancreas carcinogenesis initiated by N-nitrosobis (2-hydroxypropyl)amine in hamsters. Makino, T., Obara, T., Ura, H., Kinugasa, T., Kobayashi, H., Takahashi, S., Konishi, Y. J. Natl. Cancer Inst. (1986) [Pubmed]
  6. Effect of somatostatin on gallbladder volume and small intestinal motor activity in humans. Neri, M., Cuccurullo, F., Marzio, L. Gastroenterology (1990) [Pubmed]
  7. A decade of experiences with radioimmunoassays for cholecystokinin in The Netherlands. Jansen, J.B., Hopman, W.P., Lamers, C.B. Scand. J. Gastroenterol. Suppl. (1992) [Pubmed]
  8. Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer. Tsuchiya, Y., Sato, T., Kiyohara, C., Yoshida, K., Ogoshi, K., Nakamura, K., Yamamoto, M. J. Exp. Clin. Cancer Res. (2002) [Pubmed]
  9. The effect of ursodiol on the efficacy and safety of extracorporeal shock-wave lithotripsy of gallstones. The Dornier National Biliary Lithotripsy Study. Schoenfield, L.J., Berci, G., Carnovale, R.L., Casarella, W., Caslowitz, P., Chumley, D., Davis, R.C., Gillenwater, J.Y., Johnson, A.C., Jones, R.S. N. Engl. J. Med. (1990) [Pubmed]
  10. Fragmentation of gallstones by extracorporeal shock waves. Sauerbruch, T., Delius, M., Paumgartner, G., Holl, J., Wess, O., Weber, W., Hepp, W., Brendel, W. N. Engl. J. Med. (1986) [Pubmed]
  11. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Gohongi, T., Fukumura, D., Boucher, Y., Yun, C.O., Soff, G.A., Compton, C., Todoroki, T., Jain, R.K. Nat. Med. (1999) [Pubmed]
  12. Chenotherapy for gallstone dissolution. I. Efficacy and safety. Thistle, J.L., Hofmann, A.F., Ott, B.J., Stephens, D.H. JAMA (1978) [Pubmed]
  13. Estrogen-induced gallstone formation in males. Relation to changes in serum and biliary lipids during hormonal treatment of prostatic carcinoma. Henriksson, P., Einarsson, K., Eriksson, A., Kelter, U., Angelin, B. J. Clin. Invest. (1989) [Pubmed]
  14. Safety and efficacy of repeated shockwave lithotripsy of gallstones with and without adjuvant bile acid therapy. Sauter, G., Kullak-Ublick, G.A., Schumacher, R., Janssen, J., Greiner, L., Brand, B., Stange, E.F., Wengler, K., Lochs, H., Freytag, A., Wissing, A., Holl, J., Sackmann, M., Paumgartner, G. Gastroenterology (1997) [Pubmed]
  15. Effect of oral erythromycin on gallbladder motility in normal subjects and subjects with gallstones. Catnach, S.M., Fairclough, P.D., Trembath, R.C., O'Donnell, L.J., McLean, A.M., Law, P.A., Wickham, J.E. Gastroenterology (1992) [Pubmed]
  16. Octreotide promotes gallbladder absorption in prairie dogs: a potential cause of gallstones. Moser, A.J., Abedin, M.Z., Giurgiu, D.I., Roslyn, J.J. Gastroenterology (1995) [Pubmed]
  17. Basolateral KCl co-transport in a NaCl-absorbing epithelium. Reuss, L. Nature (1983) [Pubmed]
  18. Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK. Liddle, R.A., Gertz, B.J., Kanayama, S., Beccaria, L., Coker, L.D., Turnbull, T.A., Morita, E.T. J. Clin. Invest. (1989) [Pubmed]
  19. Effects of cholecystectomy on the kinetics of primary and secondary bile acids. Berr, F., Stellaard, F., Pratschke, E., Paumgartner, G. J. Clin. Invest. (1989) [Pubmed]
  20. Nature and composition of biliary sludge. Lee, S.P., Nicholls, J.F. Gastroenterology (1986) [Pubmed]
  21. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Hildebrand, P., Petrig, C., Burckhardt, B., Ketterer, S., Lengsfeld, H., Fleury, A., Hadváry, P., Beglinger, C. Gastroenterology (1998) [Pubmed]
  22. DNA synthesis index: higher for human gallbladders with cholesterol gallstones than with pigment gallstones. Lamote, J., Putz, P., Francois, M., Willems, G. J. Natl. Cancer Inst. (1983) [Pubmed]
  23. Tumors induced in mice by N-methyl-N-formylhydrazine of the false morel Gyromitra esculenta. Toth, B., Nagel, D. J. Natl. Cancer Inst. (1978) [Pubmed]
  24. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. Wang, D.Q., Schmitz, F., Kopin, A.S., Carey, M.C. J. Clin. Invest. (2004) [Pubmed]
  25. Cyclic nucleotides and glycoproteins during formation of cholesterol gallstones in prairie dogs. Zak, R.A., Frenkiel, P.G., Marks, J.W., Bonorris, G.G., Allen, A., Schoenfield, L.J. Gastroenterology (1984) [Pubmed]
  26. Effects of oral contraceptives on the gallbladder bile of normal women. Bennion, L.J., Ginsberg, R.L., Gernick, M.B., Bennett, P.H. N. Engl. J. Med. (1976) [Pubmed]
  27. A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus. Chang, R.S., Lotti, V.J., Monaghan, R.L., Birnbaum, J., Stapley, E.O., Goetz, M.A., Albers-Schönberg, G., Patchett, A.A., Liesch, J.M., Hensens, O.D. Science (1985) [Pubmed]
  28. Normal findings in oral and cholecystokinin cholecystography. Nathan, M.H., Newman, A., Murray, D.J. JAMA (1978) [Pubmed]
  29. Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action. Behar, J., Biancani, P. J. Clin. Invest. (1980) [Pubmed]
  30. Cholecystokinin receptors in human pancreas and gallbladder muscle: a comparative study. Tang, C., Biemond, I., Lamers, C.B. Gastroenterology (1996) [Pubmed]
  31. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. De Lisle, R.C., Petitt, M., Huff, J., Isom, K.S., Agbas, A. Gastroenterology (1997) [Pubmed]
  32. Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia. Rost, D., König, J., Weiss, G., Klar, E., Stremmel, W., Keppler, D. Gastroenterology (2001) [Pubmed]
  33. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Pastoreková, S., Parkkila, S., Parkkila, A.K., Opavský, R., Zelník, V., Saarnio, J., Pastorek, J. Gastroenterology (1997) [Pubmed]
  34. Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. Kibe, A., Holzbach, R.T., LaRusso, N.F., Mao, S.J. Science (1984) [Pubmed]
  35. Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man. Malagelada, J.R., DiMagno, E.P., Summerskill, W.H., Go, V.L. J. Clin. Invest. (1976) [Pubmed]
  36. A new subgroup of lectin-bound biliary proteins binds to cholesterol crystals, modifies crystal morphology, and inhibits cholesterol crystallization. Busch, N., Lammert, F., Marschall, H.U., Matern, S. J. Clin. Invest. (1995) [Pubmed]
  37. Pathophysiology of tumor progression in human gallbladder: flow cytometry, CEA, and CA 19-9 levels in bile and serum in different stages of gallbladder disease. Strom, B.L., Iliopoulos, D., Atkinson, B., Herlyn, M., West, S.L., Maislin, G., Saul, S., Varello, M.A., Rodriguez-Martinez, H.A., Rios-Dalenz, J. J. Natl. Cancer Inst. (1989) [Pubmed]
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