Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL129761 3-(4-methylsulfanylphenyl)-2- pyridin-4-yl...

Synonyms: SureCN7352490, CHEBI:310976, SKF-105561, SKF 105561, AC1L2W3Q, ...

Votta, B.J. et al., Olivera, D.L. et al., Marshall, P.J. et al.

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Disease relevance of SKF-105561

Analogs of SK&F 86002, which retain cytokine inhibitory activity (SK&F 104493 and SK&F 105561), inhibit bone resorption [1].

High impact information on SKF-105561

SK&F 105561 also inhibited purified PGH synthase with the potency dependent on the level of peroxidase activity [2].
SK&F 105561 inhibited partially purified 5-LO with a half-maximal concentration (IC50) of 3 microM [2].
SK&F 105561 showed weak inhibitory activity on 12-lipoxygenase with an IC50 of greater than 200 microM [2].
We report here that in vitro SK&F 105561 also blocks the production of tumor necrosis factor (TNF) from human monocytes (IC50 0.8-3 microM) [3].
In addition, the active metabolite of this compound, SK&F 105561, has been shown in vitro to inhibit the production of the inflammatory cytokine interleukin-1 (IL-1) in human monocytes stimulated with lipopolysaccharide (LPS) [3].

References

Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. Votta, B.J., Bertolini, D.R. Bone (1994) [Pubmed]
Pharmacology of the pyrroloimidazole, SK&F 105809--I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Marshall, P.J., Griswold, D.E., Breton, J., Webb, E.F., Hillegass, L.M., Sarau, H.M., Newton, J., Lee, J.C., Bender, P.E., Hanna, N. Biochem. Pharmacol. (1991) [Pubmed]
Beneficial effects of SK&F 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. Olivera, D.L., Esser, K.M., Lee, J.C., Greig, R.G., Badger, A.M. Circ. Shock (1992) [Pubmed]

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