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Chemical Compound Review:

Toxin 7 2-[bis(2-chloroethyl)amino]- 2-[4-[4-[1...

Synonyms: AC1L2XFL, 125518-25-4

Maysinger, D. et al., Valdivia, H.H. et al., Wu, X.M. et al., Kaslow, H.R. et al., Fruchart-Gaillard, C. et al.

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Disease relevance of Toxin 7

Mice were first immunized by OVA in alum and pertussis toxin 7 days before the oral feeding and given a second immunization 1 day after the oral treatment [1].

High impact information on Toxin 7

Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7 [2].
In this study a structural analog of hemicholinium-3, a,a'-bis[di(2-chloroethyl)amino]-4,4'-2-biacetophenone (toxin 7), was added to synaptosomes prepared from the cortex, striatum or hippocampus of rat brain [3].
Toxin 7, the most active toxin from this venom, selectively blocked the whole-cell inward Na+ current (INa) from guinea pig ventricular myocytes without altering the K+ or Ca2+ currents [4].
These antibodies have been termed Class A antibodies (8) and inhibit the ADP-ribosyltransferase but not the NAD glycohydrolase activity of the toxin (7) [5].

Analytical, diagnostic and therapeutic context of Toxin 7

Ultrastructural changes in the synaptosomal membrane following incubation with toxin 7 or toxin 7 with GM1 were examined by electron microscopy [3].

References

Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance. Wu, X.M., Nakashima, M., Watanabe, T. Eur. J. Immunol. (1998) [Pubmed]
Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7. Fruchart-Gaillard, C., Mourier, G., Marquer, C., Ménez, A., Servent, D. Mol. Pharmacol. (2006) [Pubmed]
Inhibition of high affinity choline uptake in the rat brain by neurotoxins: effect of monosialoganglioside GM1. Maysinger, D., Leavitt, B.R., Zorc, B., Butula, I., Fernandes, L.G., Ribeiro-da-Silva, A. Neurochem. Int. (1992) [Pubmed]
Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann. Valdivia, H.H., Martin, B.M., Ramírez, A.N., Fletcher, P.L., Possani, L.D. J. Biochem. (1994) [Pubmed]
Evaluation of antibodies elicited by immunization with pertussis toxin. Kaslow, H.R., Schlotterbeck, J.D., Gotto, J. Dev. Biol. Stand. (1991) [Pubmed]

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