The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Art1  -  ADP-ribosyltransferase 1

Mus musculus

Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1, ADPRT, ARTC1, Art2, GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Art1


Psychiatry related information on Art1

  • Treatment with r-interferon gamma or rIL-2 on days 1 through 3 after C1300-NRB inoculation significantly prolonged the mean tumor latency period, decreased the tumor growth rate, and enhanced in vitro NK killing of C1300-NRB and YAC-1 [6].

High impact information on Art1


Chemical compound and disease context of Art1


Biological context of Art1


Anatomical context of Art1


Associations of Art1 with chemical compounds

  • We have characterized the gene for mouse arginine-specific ADP-ribosyltransferase, Art1 [15].
  • Using agmatine as the ADP-ribose acceptor, the Yac-1 enzyme was predominantly an ADP-ribosyltransferase, whereas the transferase and NAD glycohydrolase activities of the recombinant Yac-2 protein were equivalent [2].
  • This messenger encodes for a precursor protein of 367 aa (MW: 41.5 kDa) which exhibits a peptide signal, consensus domains for mono(ADP-ribosyl)transferase and a C terminal part which contains three repeated motives (GEKNQKLEDH) and a region characteristic of glycophosphatidyl inositol anchored proteins [18].
  • Fluorescence-activated cell sorter analysis revealed induction of H-2Kk and beta 2m 3 days after culture of YAC-1 with DMSO, whereas optimal H-2Dd induction required more than 1 week [11].
  • Urethan (1 mg/g) inoculated into 6- to 8-week-old A/J mice produced considerable depression of cytotoxic activity of spleen cells against YAC-1 or RL male 1 tumor cells [20].

Physical interactions of Art1


Regulatory relationships of Art1


Other interactions of Art1

  • Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase [28].
  • ART2.2 is a GPI-anchored ecto-ADP-ribosyltransferase (ART) related to ADP-ribosylating bacterial toxins [29].
  • Although the cells contained dense granules reactive to mAb against perforin, they exerted no conventional cytolytic activity against YAC-1 [30].
  • Spleen cells from naive HSK-susceptible CAL-20 (Igh-1d) and BALB/c (Igh-1a) mice lysed YAC-1 targets better than HSK-resistant C.B-17 (Igh-1b) mice [31].
  • Thus, we examined the effect that dimethyl 2,2-dichlorovinyl phosphate (DDVP), an organophosphorus pesticide has on NK, CTL and LAK activities of PKO mice in vitro using the Fas antigen-positive YAC-1 cell as a target in the present study [32].

Analytical, diagnostic and therapeutic context of Art1


  1. Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes. Okazaki, I.J., Kim, H.J., McElvaney, N.G., Lesma, E., Moss, J. Blood (1996) [Pubmed]
  2. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki, I.J., Kim, H.J., Moss, J. J. Biol. Chem. (1996) [Pubmed]
  3. ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis. Black, W.J., Munoz, J.J., Peacock, M.G., Schad, P.A., Cowell, J.L., Burchall, J.J., Lim, M., Kent, A., Steinman, L., Falkow, S. Science (1988) [Pubmed]
  4. Defective cytotoxic T-cell generation in Moloney murine sarcoma virus-infected A/Sn mice. Becker, S., Klein, E. J. Natl. Cancer Inst. (1980) [Pubmed]
  5. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Yamamoto, S., Kiyono, H., Yamamoto, M., Imaoka, K., Fujihashi, K., Van Ginkel, F.W., Noda, M., Takeda, Y., McGhee, J.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. The influence of natural killer cells in neuroblastoma. Reynolds, J.V., Shou, J., Choi, H., Sigal, R., Ziegler, M.M., Daly, J.M. Archives of surgery (Chicago, Ill. : 1960) (1989) [Pubmed]
  7. Generation of lytic natural killer 1.1+, Ly-49- cells from multipotential murine bone marrow progenitors in a stroma-free culture: definition of cytokine requirements and developmental intermediates. Williams, N.S., Moore, T.A., Schatzle, J.D., Puzanov, I.J., Sivakumar, P.V., Zlotnik, A., Bennett, M., Kumar, V. J. Exp. Med. (1997) [Pubmed]
  8. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules. Bargatze, R.F., Butcher, E.C. J. Exp. Med. (1993) [Pubmed]
  9. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. Shi, L., Kraut, R.P., Aebersold, R., Greenberg, A.H. J. Exp. Med. (1992) [Pubmed]
  10. A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion. Nabel, G., Allard, W.J., Cantor, H. J. Exp. Med. (1982) [Pubmed]
  11. Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant. Yamasaki, T., Klein, G., Ljunggren, H.G., Höglund, P., Ohlén, C., Petersson, M.G., Kärre, K. J. Natl. Cancer Inst. (1988) [Pubmed]
  12. Effects of cimetidine on tumor growth and immune function in nude mice bearing human ovarian carcinoma. Kikuchi, Y., Oomori, K., Kizawa, I., Kato, K. J. Natl. Cancer Inst. (1985) [Pubmed]
  13. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Takaishi, K., Kikuchi, A., Kuroda, S., Kotani, K., Sasaki, T., Takai, Y. Mol. Cell. Biol. (1993) [Pubmed]
  14. Cure of B16F10 melanoma lung metastasis in mice by chronic indomethacin therapy combined with repeated rounds of interleukin 2: characteristics of killer cells generated in situ. Lala, P.K., Parhar, R.S. Cancer Res. (1988) [Pubmed]
  15. Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1. Braren, R., Glowacki, G., Nissen, M., Haag, F., Koch-Nolte, F. Biochem. J. (1998) [Pubmed]
  16. Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector. Adriouch, S., Ohlrogge, W., Haag, F., Koch-Nolte, F., Seman, M. J. Immunol. (2001) [Pubmed]
  17. Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout. Kanaitsuka, T., Bortell, R., Stevens, L.A., Moss, J., Sardinha, D., Rajan, T.V., Zipris, D., Mordes, J.P., Greiner, D.L., Rossini, A.A. J. Immunol. (1997) [Pubmed]
  18. Molecular cloning and characterization of a mono(ADP-ribosyl)transferase from human testis. Lévy, I., Pawlak, A., Mattéi, M.G., Guellaën, G. Adv. Exp. Med. Biol. (1997) [Pubmed]
  19. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. Paone, G., Stevens, L.A., Levine, R.L., Bourgeois, C., Steagall, W.K., Gochuico, B.R., Moss, J. J. Biol. Chem. (2006) [Pubmed]
  20. Inhibition of the activity of mouse natural killer cells by urethan. Gorelik, E., Herberman, R.B. J. Natl. Cancer Inst. (1981) [Pubmed]
  21. Class I (H-2Kb) gene transfection reduces susceptibility of YAC-1 lymphoma targets to natural killer cells. Carlow, D.A., Payne, U., Hozumi, N., Roder, J.C., Czitrom, A.A. Eur. J. Immunol. (1990) [Pubmed]
  22. Generation of neutralizing antipeptide antibodies to the enzymatic domain of Pseudomonas aeruginosa exotoxin A. Elzaim, H.S., Chopra, A.K., Peterson, J.W., Goodheart, R., Heggers, J.P. Infect. Immun. (1998) [Pubmed]
  23. Natural cell-mediated cytotoxicity (NCMC) against NK-sensitive tumours in vitro by murine spleen Ly-6C+ natural T cells. Martiniello, R., Burton, R.C., Smart, Y.C. Int. J. Cancer (1997) [Pubmed]
  24. Binding of monoclonal antibody specific for domain Ia/II of Pseudomonas aeruginosa exotoxin A at pH 4 strongly neutralizes exotoxin A-induced cytotoxicity in cell culture and in vivo. Ohtsuka, H., Horigome, K., Higuchi, A., Nomura, N., Ochi, H., Yokota, S., Kohzuki, T., Noguchi, H. Infect. Immun. (1992) [Pubmed]
  25. The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I. Akita, Y., Saito, T., Yajima, Y., Sakuma, S. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  26. Early appearance and activation of natural killer cells in tumor-infiltrating lymphoid cells during tumor development. Kurosawa, S., Matsuzaki, G., Harada, M., Ando, T., Nomoto, K. Eur. J. Immunol. (1993) [Pubmed]
  27. 3,4-Dichloroisocoumarin serine protease inhibitor induces DNA fragmentation and apoptosis in susceptible target cells. Hameed, A., Aslam, U., Ying, A.J. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  28. Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase. Hara, N., Badruzzaman, M., Sugae, T., Shimoyama, M., Tsuchiya, M. Eur. J. Biochem. (1999) [Pubmed]
  29. Metalloprotease-mediated shedding of enzymatically active mouse ecto-ADP-ribosyltransferase ART2.2 upon T cell activation. Kahl, S., Nissen, M., Girisch, R., Duffy, T., Leiter, E.H., Haag, F., Koch-Nolte, F. J. Immunol. (2000) [Pubmed]
  30. IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. Tsutsui, H., Nakanishi, K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y., Kaneda, K. J. Immunol. (1996) [Pubmed]
  31. Natural killer cellular cytotoxicity against herpes simplex virus-infected cells in Igh-1-disparate mice. Tamesis, R.R., Foster, C.S. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  32. Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice. Li, Q., Nakadai, A., Takeda, K., Kawada, T. Toxicology (2004) [Pubmed]
  33. Molecular cloning of a functional murine arginine-specific mono-ADP-ribosyltransferase and its expression in lymphoid cells. Yu, Y., Okamoto, S., Nemoto, E., Dennert, G. DNA Cell Biol. (1997) [Pubmed]
  34. Dendritic cells that have interacted with antigen are targets for natural killer cells. Shah, P.D., Gilbertson, S.M., Rowley, D.A. J. Exp. Med. (1985) [Pubmed]
  35. YAC-1 variant clones selected for resistance to natural killer cytotoxic factors are also resistant to natural killer cell-mediated cytotoxicity. Wright, S.C., Bonavida, B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  36. Changes in number and density of large granular lymphocytes upon in vivo augmentation of mouse natural killer activity. Santoni, A., Piccoli, M., Ortaldo, J.R., Mason, L., Wiltrout, R.H., Herberman, R.B. J. Immunol. (1985) [Pubmed]
WikiGenes - Universities