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Chemical Compound Review:

Sialokinin I (3S)-3-[[(1S)-5-amino-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1L31W6, 152923-41-6, Asn-thr-gly-asp-lys-phe-tyr-gly-leu-met-NH2

Zeidner, N.S. et al., Beerntsen, B.T. et al., Champagne, D.E. et al.

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Disease relevance of Sialokinin I

Sialokinin I and II: vasodilatory tachykinins from the yellow fever mosquito Aedes aegypti [1].

High impact information on Sialokinin I

Inoculation of 5-1000 ng of sialokinin-I into C3H/HeJ mice mimicked the effect of Ae. aegypti feeding by down regulating Th1 cytokines and significantly up regulating Th2 cytokines four days post inoculation [2].
Moreover, sialokinin-I and sialokinin-II mimicked the effect of mosquito feeding by modulating the host T cell response [2].
Screening of an Ae. aegypti genomic library with the cDNA resulted in the isolation of a clone containing the gene, designated Sialokinin I (Sia I) [3].

References

Sialokinin I and II: vasodilatory tachykinins from the yellow fever mosquito Aedes aegypti. Champagne, D.E., Ribeiro, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Mosquito feeding modulates Th1 and Th2 cytokines in flavivirus susceptible mice: an effect mimicked by injection of sialokinins, but not demonstrated in flavivirus resistant mice. Zeidner, N.S., Higgs, S., Happ, C.M., Beaty, B.J., Miller, B.R. Parasite Immunol. (1999) [Pubmed]
Characterization of the Sialokinin I gene encoding the salivary vasodilator of the yellow fever mosquito, Aedes aegypti. Beerntsen, B.T., Champagne, D.E., Coleman, J.L., Campos, Y.A., James, A.A. Insect Mol. Biol. (1999) [Pubmed]

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