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Chemical Compound Review

AC1Q2WCH     (2R)-N-[(1S)-1-[[(2S)-5...

Synonyms: AC1Q5JPM, AR-1I7034, S-2441, AC1L32CO, Pro-phe-N-heptyl-arg-NH2, ...
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Disease relevance of Pro-phe-N-heptyl-arg-NH2


High impact information on Pro-phe-N-heptyl-arg-NH2

  • The increase in B beta 15-42 IP seen 30 min after induction of pancreatitis and the decrease in alpha 2-antiplasmin were blunted by aprotinin, alpha 1-antitrypsin, and S-2441, but inhibition of the rise in amylase and B beta 15-42 IP only reached significance with S-2441 (P less than 0.05) [1].
  • S-2441, a kallikrein inhibitor/kinin antagonist, slightly delayed the fall in plasma prekallikrein, but no other effects were found [3].
  • Hematologic studies revealed that S-2441 significantly inhibited E. coli-induced prolongation of prothrombin time and partial thromboplastin time as well as a rapid decrease in the values of factor X, anti-thrombin III, and fibrinogen [2].

Analytical, diagnostic and therapeutic context of Pro-phe-N-heptyl-arg-NH2

  • Twenty minutes after bile-induced pancreatitis, group III was given 1.0 mg/kg aprotinin (trasylol), group IV was given 10 mg/kg S-2441, a new synthetic protease inhibitor, and group V was given 0.5 mg/kg alpha 2-antitrypsin by intravenous infusion over 10 min [1].


  1. Comparative study of protease inhibitors on coagulation abnormalities in canine pancreatitis. Izquierdo, R., Sandberg, L., Nora, M.O., Squillaci, G., Hoppensteadt, D., Walenga, J., Fareed, J., Prinz, R.A. J. Surg. Res. (1984) [Pubmed]
  2. Efficacy of S-2441, a synthetic oligopeptide, in a rat model for gram-negative bacteremia. Balis, J.U., Paterson, J.F., Fareed, J., Claeson, G., Desai, U., Shelley, S.A. Circ. Shock (1985) [Pubmed]
  3. Septic shock in the rat: activation of plasma proteolytic systems and effects of a kallikrein inhibitor/bradykinin antagonist (S-2441). Högström, H., Claeson, G., Larsson-Backström, C., Lundberg, D., Wenngren, E., Haglund, U. Acta chirurgica Scandinavica. (1987) [Pubmed]
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