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Chemical Compound Review:

Methyl, bromo- bromomethane

Synonyms: CH2Br, AC1L3G8M, 16519-97-4, Bromomethyl radical

Kundu, B. et al., Colby, J. et al., Page, B.D. et al., Colby, J. et al.

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Disease relevance of bromomethane

Extracts of Methylomonas methanica catalyse the O2-and NAD(P)H-dependent disappearance of bromomethane [1].
Soluble extracts of Methylococcus capsulatus (Bath), obtained by centrifugation of crude extracts at 160000g for 1h, catalyse the NAD(P)H- and O2-dependent disappearance of bromomethane, and also the formation of methanol from methane [2].
Here we compared the mutagenic potencies of the HNMs to those of their halomethane (HM) homologues by testing all nine HNMs and seven of the nine HMs (minus bromomethane and chloromethane) under the same conditions (the pre-incubation assay) in Salmonella TA100 +/- S9 [3].

Analytical, diagnostic and therapeutic context of bromomethane

Methyl bromide (MB, bromomethane) is determined in a variety of foods by headspace capillary gas chromatography with electron capture detection [4].

References

An improved assay for bacterial methane mono-oxygenase: some properties of the enzyme from Methylomonas methanica. Colby, J., Dalton, H., Whittenbury, R. Biochem. J. (1975) [Pubmed]
Some properties of a soluble methane mono-oxygenase from Methylococcus capsulatus strain Bath. Colby, J., Dalton, H. Biochem. J. (1976) [Pubmed]
Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra. Kundu, B., Richardson, S.D., Granville, C.A., Shaughnessy, D.T., Hanley, N.M., Swartz, P.D., Richard, A.M., DeMarini, D.M. Mutat. Res. (2004) [Pubmed]
Determination of methyl bromide in foods by headspace capillary gas chromatography with electron capture detection. Page, B.D., Avon, R.J. Journal - Association of Official Analytical Chemists. (1989) [Pubmed]

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