Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-H-90317 3-(6-aminopurin-9-yl)-2- hydroxy-propanoic...

Synonyms: SureCN2049962, NSC-625169, AC1L3TZE, CTK5H6779, NSC625169, ...

De Fazio, G. et al., Cools, M. et al., Kitaoka, S. et al.

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Disease relevance of AIDS-122589

The selectivity index of (RS)-AHPA against vaccinia virus in murine L929 cells was significantly increased if the drug was combined with 1 or 3 mM Hcy [1].
(RS)-AHPA and C-c3Ado induced chlorosis in Nicotiana tabacum leaf discs [2].
Three SAH hydrolase inhibitors, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) [(RS)-AHPA]; (RS)-9-(2,3-dihydroxypropyl)adenine [(RS)-DHPA] and the carbocyclic analog of 3-deazaadenosine (C-c3Ado) were evaluated for their inhibitory activity against tobacco mosaic virus (TMV) and potato virus X (PVX) [2].

High impact information on AIDS-122589

Treatment of the L929 cells with (RS)-AHPA caused a significant increase in AdoHcy levels, and these levels were further increased if, in addition to (RS)-AHPA, Hcy (1 mM) was added to the cell cultures [1].
As the most efficacious inhibitors emerged (S)-DHPA, C-c3 Ado, (RS)-AHPA isobutyl ester and neplanocin A, with a minimum inhibitory concentration of 60, 1.4, 1.2 and 0.2 micrograms/ml, and a selectivity index of greater than 3, 70, 80 and greater than 20, respectively [3].

References

Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine. Cools, M., Hasobe, M., De Clercq, E., Borchardt, R.T. Biochem. Pharmacol. (1990) [Pubmed]
Antiviral activity of S-adenosylhomocysteine hydrolase inhibitors against plant viruses. De Fazio, G., Alba, A.P., Vicente, M., De Clercq, E. Antiviral Res. (1990) [Pubmed]
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of rotavirus replication in vitro. Kitaoka, S., Konno, T., De Clercq, E. Antiviral Res. (1986) [Pubmed]

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