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Chemical Compound Review

AG-H-90317     3-(6-aminopurin-9-yl)-2- hydroxy-propanoic...

Synonyms: SureCN2049962, NSC-625169, AC1L3TZE, CTK5H6779, NSC625169, ...
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Disease relevance of AIDS-122589


High impact information on AIDS-122589

  • Treatment of the L929 cells with (RS)-AHPA caused a significant increase in AdoHcy levels, and these levels were further increased if, in addition to (RS)-AHPA, Hcy (1 mM) was added to the cell cultures [1].
  • As the most efficacious inhibitors emerged (S)-DHPA, C-c3 Ado, (RS)-AHPA isobutyl ester and neplanocin A, with a minimum inhibitory concentration of 60, 1.4, 1.2 and 0.2 micrograms/ml, and a selectivity index of greater than 3, 70, 80 and greater than 20, respectively [3].


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