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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Tobacco


High impact information on Tobacco

  • On the basis of the finding that caterpillar regurgitant can reduce the amount of toxic nicotine released by the tobacco plant Nicotiana tabacum, we investigate here whether specific salivary components from the caterpillar Helicoverpa zea might be responsible for this suppression [6].
  • Mutation of the virF gene leads to a weakened virulence of octopine strains on tomato and Nicotiana glauca (shrub tobacco) [7].
  • Here, we report the isolation of the first tobacco (Nicotiana tabacum) transposable element, Tnt1, which seems to be the most complete mobile retrotransposon characterized in higher plants [8].
  • Plastid atpB genes from six closely related, tentoxin-sensitive or -resistant Nicotiana species differ at codon 83, according to their response to the toxin: glutamate correlated with resistance and aspartate correlated with sensitivity [9].
  • Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1 [10].

Chemical compound and disease context of Tobacco

  • A glycoprotein antigen has been isolated from cured tobacco leaves (TGP-L) Nicotiana tabacum) and from cigarette smoke condensate (TGP-CSC) to which approximately one-third of human volunteers, smokers and non-smokers, exhibit immediate cutaneous hypersensitivity [11].
  • It was introduced, by Agrobacterium tumefaciens-mediated gene transfer, into an isoleucine-requiring Nicotiana plumbaginifolia auxotroph deficient in threonine dehydratase [12].
  • We expressed our model allergen Bet v 1, the major birch pollen allergen, in the tobacco-related species Nicotiana benthamiana using a tobacco mosaic virus vector [13].
  • In this study, we investigated the role of benzoic acid (BA) as precursor of SA biosynthesis in tobacco (Nicotiana tabacum cv Samsun NN) plants undergoing a hypersensitive response following infection with tobacco mosaic virus or in tobacco cell suspensions elicited with beta-megaspermin, an elicitor from Phytophthora megasperma [14].
  • We describe here the isolation of a tobacco (Nicotiana tabacum L. cv bright yellow 2 [NT1]) cDNA clone (E3) that encodes a 58.4-kD protein that shares 80% sequence similarity and 65% identity with the Anabaena biotin carboxylase subunit of ACCase [15].

Biological context of Tobacco


Anatomical context of Tobacco


Associations of Tobacco with chemical compounds

  • The induction of manganese superoxide dismutase in response to stress in Nicotiana plumbaginifolia [26].
  • Using a conditional gain-of-function transgenic system, we demonstrated that the activation of SIPK, a tobacco (Nicotiana tabacum) stress-responsive MAPK, induces the biosynthesis of ethylene [27].
  • Both cytokinin (N6-benzyladenine [BA]) and auxin (2,4-dichlorophenoxyacetic acid [2,4-D]) stimulate the accumulation of an mRNA, represented by the cDNA pLS216, in Nicotiana plumbaginifolia suspension culture cells [28].
  • We previously identified SNAREs SYP121/Syr1 from tobacco (Nicotiana tabacum) and the Arabidopsis thaliana homolog SYP121 associated with abscisic acid and drought stress [29].
  • Further activation experiments with the lbc3 and the leaf-specific Nicotiana plumbaginifolia ribulose bisphosphate carboxylase/oxygenase small subunit (rbcS-8B) promoter suggested that another specific cis element(s) is required for the function of NAT2 BS1 [30].

Gene context of Tobacco

  • Inoculation studies with TBSV mutants and the PVX derivatives demonstrated that p19 induced a generalized necrosis upon systemic infection of Nicotiana benthamiana and N. clevelandii [31].
  • Confocal laser scanning immunofluorescence studies performed on tobacco (Nicotiana tabacum) BY-2 cells revealed high degrees of colabeling between all three retromer antisera and the prevacuolar compartment (PVC) markers PEP12 and vacuolar sorting receptor VSR(At-1) [32].
  • Complementation of a threonine dehydratase-deficient Nicotiana plumbaginifolia mutant after Agrobacterium tumefaciens-mediated transfer of the Saccharomyces cerevisiae ILV1 gene [12].
  • COX17 was identified by investigating the hypersensitive response-like necrotic response provoked in tobacco (Nicotiana tabacum) leaves after harpin inoculation [33].
  • We have previously shown that transgenic expression of a truncated C1 gene of Tomato yellow leaf curl Sardinia virus (TYLCSV), expressing the first 210 amino acids of the replication-associated protein (T-Rep) and potentially coexpressing the C4 protein, confers resistance to the homologous virus in Nicotiana benthamiana plants [34].

Analytical, diagnostic and therapeutic context of Tobacco


  1. Light-inducible and chloroplast-associated expression of a chimaeric gene introduced into Nicotiana tabacum using a Ti plasmid vector. Herrera-Estrella, L., Van den Broeck, G., Maenhaut, R., Van Montagu, M., Schell, J., Timko, M., Cashmore, A. Nature (1984) [Pubmed]
  2. Letter: Action of hepatitis-B antigen on Nicotiana sylvestris and Vigna sinensis. Dhalival, A.S., Rubinstein, H.M., Dietz, A.A. Lancet (1975) [Pubmed]
  3. Plasmodesmatal function is probed using transgenic tobacco plants that express a virus movement protein. Wolf, S., Deom, C.M., Beachy, R., Lucas, W.J. Plant Cell (1991) [Pubmed]
  4. Identification of an elicitor active site within the three-dimensional structure of the tobacco mosaic tobamovirus coat protein. Taraporewala, Z.F., Culver, J.N. Plant Cell (1996) [Pubmed]
  5. Peptide-mediated broad-spectrum plant resistance to tospoviruses. Rudolph, C., Schreier, P.H., Uhrig, J.F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Herbivory: caterpillar saliva beats plant defences. Musser, R.O., Hum-Musser, S.M., Eichenseer, H., Peiffer, M., Ervin, G., Murphy, J.B., Felton, G.W. Nature (2002) [Pubmed]
  7. Transgenic N. glauca plants expressing bacterial virulence gene virF are converted into hosts for nopaline strains of A. tumefaciens. Regensburg-Tuïnk, A.J., Hooykaas, P.J. Nature (1993) [Pubmed]
  8. Tnt1, a mobile retroviral-like transposable element of tobacco isolated by plant cell genetics. Grandbastien, M.A., Spielmann, A., Caboche, M. Nature (1989) [Pubmed]
  9. Tentoxin sensitivity of chloroplasts determined by codon 83 of beta subunit of proton-ATPase. Avni, A., Anderson, J.D., Holland, N., Rochaix, J.D., Gromet-Elhanan, Z., Edelman, M. Science (1992) [Pubmed]
  10. Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1. Lloyd, A.M., Walbot, V., Davis, R.W. Science (1992) [Pubmed]
  11. Tobacco, cocoa, coffee, and ragweed: cross-reacting allergens that activate factor-XII-dependent pathways. Becker, C.G., Van Hamont, N., Wagner, M. Blood (1981) [Pubmed]
  12. Complementation of a threonine dehydratase-deficient Nicotiana plumbaginifolia mutant after Agrobacterium tumefaciens-mediated transfer of the Saccharomyces cerevisiae ILV1 gene. Colau, D., Negrutiu, I., Van Montagu, M., Hernalsteens, J.P. Mol. Cell. Biol. (1987) [Pubmed]
  13. Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization. Krebitz, M., Wiedermann, U., Essl, D., Steinkellner, H., Wagner, B., Turpen, T.H., Ebner, C., Scheiner, O., Breiteneder, H. FASEB J. (2000) [Pubmed]
  14. Free and conjugated benzoic acid in tobacco plants and cell cultures. Induced accumulation upon elicitation of defense responses and role as salicylic acid precursors. Chong, J., Pierrel, M.A., Atanassova, R., Werck-Reichhart, D., Fritig, B., Saindrenan, P. Plant Physiol. (2001) [Pubmed]
  15. Structural analysis, plastid localization, and expression of the biotin carboxylase subunit of acetyl-coenzyme A carboxylase from tobacco. Shorrosh, B.S., Roesler, K.R., Shintani, D., van de Loo, F.J., Ohlrogge, J.B. Plant Physiol. (1995) [Pubmed]
  16. KNOX homeodomain protein directly suppresses the expression of a gibberellin biosynthetic gene in the tobacco shoot apical meristem. Sakamoto, T., Kamiya, N., Ueguchi-Tanaka, M., Iwahori, S., Matsuoka, M. Genes Dev. (2001) [Pubmed]
  17. Wheat germ splicing endonuclease is highly specific for plant pre-tRNAs. Stange, N., Gross, H.J., Beier, H. EMBO J. (1988) [Pubmed]
  18. Constitutive expression of nitrate reductase allows normal growth and development of Nicotiana plumbaginifolia plants. Vincentz, M., Caboche, M. EMBO J. (1991) [Pubmed]
  19. Use of a gene expression system based on potato virus X to rapidly identify and characterize a tomato Pto homolog that controls fenthion sensitivity. Rommens, C.M., Salmeron, J.M., Baulcombe, D.C., Staskawicz, B.J. Plant Cell (1995) [Pubmed]
  20. Extracellular invertase is an essential component of cytokinin-mediated delay of senescence. Balibrea Lara, M.E., Gonzalez Garcia, M.C., Fatima, T., Ehness, R., Lee, T.K., Proels, R., Tanner, W., Roitsch, T. Plant Cell (2004) [Pubmed]
  21. Changing patterns of localization of the tobacco mosaic virus movement protein and replicase to the endoplasmic reticulum and microtubules during infection. Heinlein, M., Padgett, H.S., Gens, J.S., Pickard, B.G., Casper, S.J., Epel, B.L., Beachy, R.N. Plant Cell (1998) [Pubmed]
  22. A DNA sequence required for geminivirus replication also mediates transcriptional regulation. Eagle, P.A., Orozco, B.M., Hanley-Bowdoin, L. Plant Cell (1994) [Pubmed]
  23. Chloroplasts of higher plants synthesize L-phenylalanine via L-arogenate. Jung, E., Zamir, L.O., Jensen, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. A plant plasma membrane H+-ATPase expressed in yeast is activated by phosphorylation at its penultimate residue and binding of 14-3-3 regulatory proteins in the absence of fusicoccin. Maudoux, O., Batoko, H., Oecking, C., Gevaert, K., Vandekerckhove, J., Boutry, M., Morsomme, P. J. Biol. Chem. (2000) [Pubmed]
  25. The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity. Bracha, K., Lavy, M., Yalovsky, S. J. Biol. Chem. (2002) [Pubmed]
  26. The induction of manganese superoxide dismutase in response to stress in Nicotiana plumbaginifolia. Bowler, C., Alliotte, T., De Loose, M., Van Montagu, M., Inzé, D. EMBO J. (1989) [Pubmed]
  27. Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. Liu, Y., Zhang, S. Plant Cell (2004) [Pubmed]
  28. Cytokinins and auxins control the expression of a gene in Nicotiana plumbaginifolia cells by feedback regulation. Dominov, J.A., Stenzler, L., Lee, S., Schwarz, J.J., Leisner, S., Howell, S.H. Plant Cell (1992) [Pubmed]
  29. Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane. Sutter, J.U., Campanoni, P., Tyrrell, M., Blatt, M.R. Plant Cell (2006) [Pubmed]
  30. A protein binding AT-rich sequence in the soybean leghemoglobin c3 promoter is a general cis element that requires proximal DNA elements to stimulate transcription. Laursen, N.B., Larsen, K., Knudsen, J.Y., Hoffmann, H.J., Poulsen, C., Marcker, K.A., Jensen, E.O. Plant Cell (1994) [Pubmed]
  31. Identification of tomato bushy stunt virus host-specific symptom determinants by expression of individual genes from a potato virus X vector. Scholthof, H.B., Scholthof, K.B., Jackson, A.O. Plant Cell (1995) [Pubmed]
  32. Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Oliviusson, P., Heinzerling, O., Hillmer, S., Hinz, G., Tse, Y.C., Jiang, L., Robinson, D.G. Plant Cell (2006) [Pubmed]
  33. AtCOX17, an Arabidopsis homolog of the yeast copper chaperone COX17. Balandin, T., Castresana, C. Plant Physiol. (2002) [Pubmed]
  34. Transgenically expressed T-Rep of tomato yellow leaf curl Sardinia virus acts as a trans-dominant-negative mutant, inhibiting viral transcription and replication. Brunetti, A., Tavazza, R., Noris, E., Lucioli, A., Accotto, G.P., Tavazza, M. J. Virol. (2001) [Pubmed]
  35. Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. Thai, L., Rush, J.S., Maul, J.E., Devarenne, T., Rodgers, D.L., Chappell, J., Waechter, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  36. DNA methylation, vernalization, and the initiation of flowering. Burn, J.E., Bagnall, D.J., Metzger, J.D., Dennis, E.S., Peacock, W.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  37. Cytokinins in tobacco and wheat chloroplasts. Occurrence and changes due to light/dark treatment. Benková, E., Witters, E., Van Dongen, W., Kolár, J., Motyka, V., Brzobohatý, B., Van Onckelen, H.A., Machácková, I. Plant Physiol. (1999) [Pubmed]
  38. Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence. Maxwell, D.P., Nickels, R., McIntosh, L. Plant J. (2002) [Pubmed]
  39. Interaction between a geminivirus replication protein and the plant sumoylation system. Castillo, A.G., Kong, L.J., Hanley-Bowdoin, L., Bejarano, E.R. J. Virol. (2004) [Pubmed]
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