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Chemical Compound Review

Swietenose     (2R,3S,4S,5R)-2,3,4,5- tetrahydroxy-6-[(3R...

Synonyms: AC1L45YF, 6-O-Galactopyranosylgalactose, 6-O-beta-D-Galactopyranosyl-D-galactose, D-Galactose, 6-O-beta-D-galactopyranosyl-
 
 
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Disease relevance of Swietenose

  • Unlike their chicken egg white counterparts, PEW glycoproteins contain terminal Galalpha1-4Gal, as evidenced by GS-I lectin (specific for terminal alpha-Gal), anti-P(1) (Galalpha1-4Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta1-1Cer) monoclonal antibody, and P fimbriae on uropathogenic Escherichia coli (specific for Galalpha1-4Gal) [1].
 

High impact information on Swietenose

  • Our results revealed that the expression of Galalpha1-4Gal glycoproteins is not rare among avians, and is correlated with the phylogeny [2].
  • We now report that Galalpha1-4Gal-bearing glycoproteins are also present in pigeon serum, lymphocytes, and liver, as probed by Western blot with Griffonia simplicifolia-I lectin (specific for terminal alpha-Gal) and anti-P1 (specific for Galalpha1-4Galbeta1-4GlcNAcbeta1-) monoclonal antibody [3].
  • Earlier results from our laboratory suggested that an association of IFNAR-1 with membrane Galalpha1-4Gal-containing glycolipids facilitates receptor-mediated signaling [4].

References

 
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